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    Fyb1 FYN binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 23880, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fyb1provided by MGI
    Official Full Name
    FYN binding protein 1provided by MGI
    Primary source
    MGI:MGI:1346327
    See related
    Ensembl:ENSMUSG00000022148 AllianceGenome:MGI:1346327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fyb; ADAP; Slap130; p120/130; p120/p130; FYB-120/130; B630013F22Rik
    Summary
    The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
    Expression
    Biased expression in thymus adult (RPKM 13.6), spleen adult (RPKM 5.7) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fyb1 in Genome Data Viewer
    Location:
    15 A1; 15 3.19 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (6552280..6695089)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (6522796..6665608)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene disabled 2, mitogen-responsive phosphoprotein Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene complement component 9 Neighboring gene STARR-seq mESC enhancer starr_37861 Neighboring gene STARR-seq mESC enhancer starr_37865 Neighboring gene predicted gene 2245 Neighboring gene STARR-seq mESC enhancer starr_37866 Neighboring gene prohibitin pseudogene Neighboring gene STARR-seq mESC enhancer starr_37870 Neighboring gene RPTOR independent companion of MTOR, complex 2 Neighboring gene predicted gene, 53882 Neighboring gene oncostatin M receptor Neighboring gene predicted gene, 41261

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    NOT acts_upstream_of_or_within mast cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    FYN-binding protein 1
    Names
    FYN binding protein FYB-130
    FYN-T-binding protein
    SLP-76-associated phosphoprotein
    adhesion and degranulation promoting adaptor protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278269.1NP_001265198.1  FYN-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001265198.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AC158901, AC161196, AK137907
      UniProtKB/Swiss-Prot
      O35601
      Conserved Domains (2) summary
      pfam14603
      Location:691773
      hSH3; Helically-extended SH3 domain
      cl17036
      Location:496591
      SH3; Src Homology 3 domain superfamily
    2. NM_011815.5NP_035945.1  FYN-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_035945.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC158901, AC161196
      Consensus CDS
      CCDS37031.1
      UniProtKB/Swiss-Prot
      O35601, Q9Z2H3
      UniProtKB/TrEMBL
      B2RUR0
      Related
      ENSMUSP00000087947.6, ENSMUST00000090461.12
      Conserved Domains (2) summary
      pfam14603
      Location:737819
      hSH3; Helically-extended SH3 domain
      cl17036
      Location:496591
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      6552280..6695089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245328.3XP_011243630.1  FYN-binding protein 1 isoform X1

      Conserved Domains (2) summary
      pfam07653
      Location:513568
      SH3_2; Variant SH3 domain
      pfam14603
      Location:750837
      hSH3; Helically-extended SH3 domain
    2. XM_011245329.3XP_011243631.1  FYN-binding protein 1 isoform X4

      Conserved Domains (2) summary
      pfam07653
      Location:513568
      SH3_2; Variant SH3 domain
      pfam14603
      Location:704791
      hSH3; Helically-extended SH3 domain
    3. XM_006519982.2XP_006520045.1  FYN-binding protein 1 isoform X2

      Conserved Domains (2) summary
      pfam07653
      Location:513568
      SH3_2; Variant SH3 domain
      pfam14603
      Location:742829
      hSH3; Helically-extended SH3 domain
    4. XM_006519985.2XP_006520048.1  FYN-binding protein 1 isoform X5

      Conserved Domains (2) summary
      pfam07653
      Location:513568
      SH3_2; Variant SH3 domain
      pfam14603
      Location:696783
      hSH3; Helically-extended SH3 domain
    5. XM_036159389.1XP_036015282.1  FYN-binding protein 1 isoform X6

      Conserved Domains (1) summary
      cl17036
      Location:506601
      SH3; Src Homology 3 domain superfamily
    6. XM_006519983.4XP_006520046.1  FYN-binding protein 1 isoform X3

      Conserved Domains (2) summary
      pfam07653
      Location:503558
      SH3_2; Variant SH3 domain
      pfam14603
      Location:740827
      hSH3; Helically-extended SH3 domain
    7. XM_006519986.1XP_006520049.1  FYN-binding protein 1 isoform X7

      Conserved Domains (2) summary
      pfam07653
      Location:73128
      SH3_2; Variant SH3 domain
      pfam14603
      Location:310397
      hSH3; Helically-extended SH3 domain