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    Slu7 SLU7 splicing factor homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 193116, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slu7provided by MGI
    Official Full Name
    SLU7 splicing factor homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:2385598
    See related
    Ensembl:ENSMUSG00000020409 AllianceGenome:MGI:2385598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D3Bwg0878e; D11Ertd730e
    Summary
    Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.7), cerebellum adult (RPKM 5.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slu7 in Genome Data Viewer
    Location:
    11 B1.1; 11 25.68 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (43324550..43338809)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43433726..43447982)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5782 Neighboring gene STARR-positive B cell enhancer ABC_E3940 Neighboring gene pituitary tumor-transforming gene 1 Neighboring gene STARR-positive B cell enhancer ABC_E6968 Neighboring gene predicted gene 12151 Neighboring gene C1q and tumor necrosis factor related protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing. Chua K, et al. Mol Cell Biol, 2001 Mar. PMID 11238888, Free PMC Article
    2. Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice. Wang J, et al. Am J Pathol, 2018 Aug. PMID 29870742, Free PMC Article
    3. Splicing regulator SLU7 is essential for maintaining liver homeostasis. Elizalde M, et al. J Clin Invest, 2014 Jul. PMID 24865429, Free PMC Article
    4. The RNA splicing factor hSlu7 is required for correct 3' splice-site choice. Chua K, et al. Nature, 1999 Nov 11. PMID 10647016
    5. Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage. Gárate-Rascón M, et al. Hepatology, 2021 Nov. PMID 34170569

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4alpha Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
      Title: Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
    2. Knockdown of hepatic Slu7 by adenovirus-Slu7shRNA treatment ameliorated inflammation and attenuated liver injury in mice after ethanol administration.
      Title: Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice.
    3. SLU7 knockdown in liver resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern.
      Title: Splicing regulator SLU7 is essential for maintaining liver homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31026

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pre-mRNA 3'-splice site binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pre-mRNA 3'-splice site binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables second spliceosomal transesterification activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables second spliceosomal transesterification activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA splicing, via transesterification reactions ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA splicing, via transesterification reactions ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA 3'-splice site recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-splice site recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of small nuclear ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small nuclear ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA-splicing factor SLU7
    Names
    step II splicing factor SLU7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148673.3 → NP_683514.2  pre-mRNA-splicing factor SLU7

      See identical proteins and their annotated locations for NP_683514.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK029117, AK047597, BY243619
      Consensus CDS
      CCDS24557.1
      UniProtKB/Swiss-Prot
      Q3KQQ3, Q5SRU1, Q63ZX3, Q6P923, Q8BHJ9, Q8BL59, Q8BXD5, Q8R5C1, Q91YV6
      UniProtKB/TrEMBL
      Z4YM25
      Related
      ENSMUSP00000116609.2, ENSMUST00000151880.8
      Conserved Domains (1) summary
      pfam11708
      Location:161 → 434
      Slu7; Pre-mRNA splicing Prp18-interacting factor

    2. NM_198936.1 → NP_945174.1  pre-mRNA-splicing factor SLU7

      See identical proteins and their annotated locations for NP_945174.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional segment in its 5' UTR when compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK029117, AK047597, BY243619
      Consensus CDS
      CCDS24557.1
      UniProtKB/Swiss-Prot
      Q3KQQ3, Q5SRU1, Q63ZX3, Q6P923, Q8BHJ9, Q8BL59, Q8BXD5, Q8R5C1, Q91YV6
      UniProtKB/TrEMBL
      Z4YM25
      Related
      ENSMUSP00000020681.4, ENSMUST00000020681.10
      Conserved Domains (1) summary
      pfam11708
      Location:161 → 434
      Slu7; Pre-mRNA splicing Prp18-interacting factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      43324550..43338809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248823.3 → XP_011247125.1  pre-mRNA-splicing factor SLU7 isoform X1

      See identical proteins and their annotated locations for XP_011247125.1

      UniProtKB/Swiss-Prot
      Q3KQQ3, Q5SRU1, Q63ZX3, Q6P923, Q8BHJ9, Q8BL59, Q8BXD5, Q8R5C1, Q91YV6
      UniProtKB/TrEMBL
      Z4YM25
      Conserved Domains (1) summary
      pfam11708
      Location:161 → 434
      Slu7; Pre-mRNA splicing Prp18-interacting factor

    2. XM_036156451.1 → XP_036012344.1  pre-mRNA-splicing factor SLU7 isoform X2

      Conserved Domains (1) summary
      pfam11708
      Location:2 → 275
      Slu7; Pre-mRNA splicing Prp18-interacting factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHJ9.1 GenPept UniProtKB/Swiss-Prot:Q8BHJ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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