Ero1b endoplasmic reticulum oxidoreductase 1 beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ero1bprovided by MGI
Official Full Name: endoplasmic reticulum oxidoreductase 1 betaprovided by MGI
Primary source: MGI:MGI:1914725
See related: Ensembl:ENSMUSG00000057069 AllianceGenome:MGI:1914725
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ero1lb; ero1-beta; 1300013B24Rik; 1700065B09Rik
Summary: Enables protein-disulfide reductase activity. Involved in insulin processing. Acts upstream of or within several processes, including cell redox homeostasis; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and protein maturation by protein folding. Located in membrane. Is active in endoplasmic reticulum lumen. Is expressed in heart and hindlimb joint. Orthologous to human ERO1B (endoplasmic reticulum oxidoreductase 1 beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 15.0), spleen adult (RPKM 5.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A1; 13 5.07 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (12580701..12624422)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (12565818..12609533)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in diabetic model mice, ERO1beta expression is paradoxically decreased in beta cells despite the indications of increased ER stress
Title: Deregulation of pancreas-specific oxidoreductin ERO1β in the pathogenesis of diabetes mellitus.
combined loss-of-function mutations in genes encoding the ER thiol oxidases ERO1alpha, ERO1beta, and PRDX4 compromised the extracellular matrix and interfered with the intracellular maturation of procollagen
Title: Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice.
Several lines of evidence suggest that ERO1lbeta is involved in maintaining insulin content of pancreatic beta cells and in regulating beta cell survival during ER oxidative stress.
Title: Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells.
An unexpectedly selective function for ERO1-beta in oxidative protein folding in insulin-producing cells that is required for glucose homeostasis in vivo.
Title: ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables disulfide oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables disulfide oxidoreductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-disulfide reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-disulfide reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-disulfide reductase activity	ISO Inferred from Sequence Orthology more info
enables thiol oxidase activity	IEA Inferred from Electronic Annotation more info
enables thiol oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell redox homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein folding in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in protein folding in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein maturation by protein folding	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein maturation by protein folding	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ERO1-like protein beta

Names: ERO1-L-beta; ERO1-like beta; endoplasmic oxidoreductase 1 beta; endoplasmic oxidoreductin-1-like protein B; endoplasmic reticulum oxidoreductase beta; endoplasmic reticulum oxidoreductin-1-like protein B; oxidoreductin-1-L-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418471.1 → NP_001405400.1 ERO1-like protein beta isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CT954220

UniProtKB/TrEMBL

A0A1Y7VNF4

Related

ENSMUSP00000152393.2, ENSMUST00000221560.2
NM_001418478.1 → NP_001405407.1 ERO1-like protein beta isoform 3 precursor

Status: VALIDATED

Source sequence(s)

CT954220
NM_001418479.1 → NP_001405408.1 ERO1-like protein beta isoform 4 precursor

Status: VALIDATED

Source sequence(s)

CT954220
NM_001418481.1 → NP_001405410.1 ERO1-like protein beta isoform 5 precursor

Status: VALIDATED

Source sequence(s)

CT954220
NM_026184.3 → NP_080460.2 ERO1-like protein beta isoform 2 precursor

See identical proteins and their annotated locations for NP_080460.2

Status: VALIDATED

Source sequence(s)

CT954220

Consensus CDS

CCDS36594.1

UniProtKB/Swiss-Prot

Q14DN0, Q8R2E9

UniProtKB/TrEMBL

Q14DR9

Related

ENSMUSP00000071864.7, ENSMUST00000071973.8

Conserved Domains (1) summary

pfam04137
Location:56 → 454

ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

12580701..12624422

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516731.5 → XP_006516794.1 ERO1-like protein beta isoform X2

UniProtKB/TrEMBL

Q14DR9

Conserved Domains (1) summary

pfam04137
Location:56 → 454

ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
XM_006516732.4 → XP_006516795.1 ERO1-like protein beta isoform X3

UniProtKB/TrEMBL

Q14DR9

Related

ENSMUSP00000152543.2, ENSMUST00000220811.2

Conserved Domains (1) summary

pfam04137
Location:56 → 448

ERO1; Endoplasmic Reticulum Oxidoreductin 1 (ERO1)