Prpf4b pre-mRNA processing factor 4B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prpf4bprovided by MGI
Official Full Name: pre-mRNA processing factor 4Bprovided by MGI
Primary source: MGI:MGI:109584
See related: Ensembl:ENSMUSG00000021413 AllianceGenome:MGI:109584
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Prp4; Prpk; Prp4k; cbp143; 2610037H07
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in positive regulation of protein export from nucleus; regulation of intracellular signal transduction; and spliceosomal tri-snRNP complex assembly. Located in chromosome. Is expressed in several structures, including cerebral cortex; early conceptus; oocyte; and pancreas epithelium. Orthologous to human PRP4K (pre-mRNA processing factor kinase PRP4K). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 19.1), limb E14.5 (RPKM 16.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.3; 13 14.21 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (35058803..35090047)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (34874820..34906064)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.
Title: Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6S1932 (e-PCR)
- UniSTS:57909

PRP4 (e-PCR)
- UniSTS:266141

ha2176 (e-PCR)
- UniSTS:515498

NoName (e-PCR)
- UniSTS:236990

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mRNA cis splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal snRNP assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in spliceosomal tri-snRNP complex assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal tri-snRNP complex assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase PRP4 homolog

Names: PRP4 pre-mRNA processing factor 4 homolog B; PRP4 pre-mRNA-processing factor 4 homolog; pre-mRNA protein kinase

NP_038858.2

EC 2.7.11.1

XP_006516645.1

EC 2.7.11.1

XP_006516647.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013830.3 → NP_038858.2 serine/threonine-protein kinase PRP4 homolog

See identical proteins and their annotated locations for NP_038858.2

Status: VALIDATED

Source sequence(s)

AC124537, AC132344

Consensus CDS

CCDS26448.1

UniProtKB/Swiss-Prot

B2RUN6, O88378, Q61136, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0

UniProtKB/TrEMBL

C7G3P2

Related

ENSMUSP00000077019.4, ENSMUST00000077853.5

Conserved Domains (2) summary

PTZ00449
Location:171 → 393

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd14135
Location:686 → 1003

STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

RNA

NR_165078.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC124537, AC132344
NR_165079.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC124537, AC132344

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

35058803..35090047

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516584.4 → XP_006516647.1 serine/threonine-protein kinase PRP4 homolog isoform X2

UniProtKB/TrEMBL

C7G3P2

Conserved Domains (2) summary

PTZ00449
Location:171 → 393

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cl21453
Location:686 → 860

PKc_like; Protein Kinases, catalytic domain
XM_006516582.4 → XP_006516645.1 serine/threonine-protein kinase PRP4 homolog isoform X1

UniProtKB/TrEMBL

C7G3P2

Conserved Domains (2) summary

PTZ00449
Location:171 → 393

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cl21453
Location:686 → 860

PKc_like; Protein Kinases, catalytic domain