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    Dnajc8 DnaJ heat shock protein family (Hsp40) member C8 [ Mus musculus (house mouse) ]

    Gene ID: 68598, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dnajc8provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C8provided by MGI
    Primary source
    MGI:MGI:1915848
    See related
    Ensembl:ENSMUSG00000054405 AllianceGenome:MGI:1915848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110021D09Rik; 2010009J04Rik
    Summary
    Predicted to enable Hsp70 protein binding activity. Predicted to be located in cytosol; intercellular bridge; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system and retina. Orthologous to human DNAJC8 (DnaJ heat shock protein family (Hsp40) member C8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 60.5), liver E14 (RPKM 51.9) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dnajc8 in Genome Data Viewer
    Location:
    4 D2.3; 4 65.52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132262859..132281053)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132535559..132553742)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11570 Neighboring gene STARR-seq mESC enhancer starr_11571 Neighboring gene STARR-seq mESC enhancer starr_11572 Neighboring gene nuclear encoded tRNA alanine 8 (anticodon AGC) Neighboring gene STARR-positive B cell enhancer ABC_E9240 Neighboring gene STARR-positive B cell enhancer ABC_E9013 Neighboring gene ATP synthase inhibitory factor subunit 1 Neighboring gene predicted gene, 24762 Neighboring gene predicted gene, 54261 Neighboring gene STARR-positive B cell enhancer ABC_E10263 Neighboring gene platelet-activating factor receptor Neighboring gene STARR-seq mESC enhancer starr_11574 Neighboring gene STARR-seq mESC enhancer starr_11575 Neighboring gene STARR-seq mESC enhancer starr_11576 Neighboring gene EYA transcriptional coactivator and phosphatase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 8
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172400.3NP_765988.2  dnaJ homolog subfamily C member 8

      See identical proteins and their annotated locations for NP_765988.2

      Status: VALIDATED

      Source sequence(s)
      AK168645, BC064732, BY754536
      Consensus CDS
      CCDS51319.1
      UniProtKB/Swiss-Prot
      Q6NZB0, Q6PG72, Q8C2M6
      UniProtKB/TrEMBL
      A2ALF0, A2ALF2
      Related
      ENSMUSP00000092242.4, ENSMUST00000094657.10
      Conserved Domains (2) summary
      cd06257
      Location:57112
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      COG2214
      Location:51238
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132262859..132281053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164392.1XP_036020285.1  dnaJ homolog subfamily C member 8 isoform X1

      Conserved Domains (2) summary
      cd06257
      Location:76131
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      COG2214
      Location:70257
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]