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    Dppa2 developmental pluripotency associated 2 [ Mus musculus (house mouse) ]

    Gene ID: 73703, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dppa2provided by MGI
    Official Full Name
    developmental pluripotency associated 2provided by MGI
    Primary source
    MGI:MGI:2157523
    See related
    Ensembl:ENSMUSG00000072419 AllianceGenome:MGI:2157523
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D19Mgi18; ECAT15-2; 2410088E07Rik
    Summary
    Enables chromatin binding activity. Acts upstream of or within several processes, including epigenetic regulation of gene expression; lung-associated mesenchyme development; and positive regulation of stem cell proliferation. Located in nucleus. Is expressed in several structures, including early conceptus; gonad; liver; primordial germ cell; and trunk. Orthologous to human DPPA2 (developmental pluripotency associated 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Dppa2 in Genome Data Viewer
    Location:
    16 B5; 16 30.75 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48130637..48139876)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (48310274..48319513)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40940 Neighboring gene STARR-seq mESC enhancer starr_40944 Neighboring gene developmental pluripotency associated 4 Neighboring gene predicted gene 5485 Neighboring gene STARR-seq mESC enhancer starr_40947 Neighboring gene microrchidia 1 Neighboring gene STARR-seq mESC enhancer starr_40948 Neighboring gene STARR-seq mESC enhancer starr_40950 Neighboring gene STARR-seq mESC enhancer starr_40952 Neighboring gene STARR-seq mESC enhancer starr_40956 Neighboring gene predicted gene, 41458

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dppa2 knockdown-induced differentiation and repressed proliferation of mouse embryonic stem cells. Du J, et al. J Biochem, 2010 Feb. PMID 19846433
    2. [Molecular cloning and characterization analysis of HPESCRG1, a novel gene expressed specifically in human embryonic stem cell]. Du J, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2004 Dec. PMID 15583978
    3. Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development. Gretarsson KH, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32572256
    4. Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment. Eckersley-Maslin MA, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32572255, Free PMC Article
    5. Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome. Lim PSL, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32572253

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival.
      Title: Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival.
    2. DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development.
      Title: DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development.
    3. Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region.
      Title: Dppa2/4 as a trigger of signaling pathways to promote zygote genome activation by binding to CG-rich region.
    4. Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development.
      Title: Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development.
    5. Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment.
      Title: Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment.
    6. Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome.
      Title: Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome.
    7. The paralog proteins DPPA2 and DPPA4 as necessary for the activation of Dux and LINE-1 expression in mESCs.
      Title: DPPA2 and DPPA4 are necessary to establish a 2C-like state in mouse embryonic stem cells.
    8. Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency
      Title: Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency.
    9. Dppa2 and Dppa4 directly regulate the 2C-like cell population and associated transcripts, including Dux and the Zscan4 cluster.
      Title: Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program.
    10. a novel long non-coding RNA was found to silence its neighboring gene, Dppa2, in cis through recruiting Dnmt1, Dnmt3a and Dnmt3b
      Title: LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung-associated mesenchyme development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lung-associated mesenchyme development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    developmental pluripotency-associated protein 2
    Names
    embryonic stem cell-associated transcript 15-2 protein
    pluripotent embryonic stem cell-related gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028615.1 → NP_082891.1  developmental pluripotency-associated protein 2

      See identical proteins and their annotated locations for NP_082891.1

      Status: PROVISIONAL

      Source sequence(s)
      AY561246
      Consensus CDS
      CCDS37350.1
      UniProtKB/Swiss-Prot
      Q9CWH0
      UniProtKB/TrEMBL
      B2RQ54
      Related
      ENSMUSP00000110183.4, ENSMUST00000097175.5
      Conserved Domains (3) summary
      smart00513
      Location:91 → 118
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam14047
      Location:211 → 277
      DCR; Dppa2/4 conserved region
      pfam14049
      Location:126 → 206
      Dppa2_A; Dppa2/4 conserved region in higher vertebrates

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      48130637..48139876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWH0.1 GenPept UniProtKB/Swiss-Prot:Q9CWH0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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