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    Klhl20 kelch-like 20 [ Mus musculus (house mouse) ]

    Gene ID: 226541, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl20provided by MGI
    Official Full Name
    kelch-like 20provided by MGI
    Primary source
    MGI:MGI:2444855
    See related
    Ensembl:ENSMUSG00000026705 AllianceGenome:MGI:2444855
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kleip; mKIAA4210; D930050H05Rik
    Summary
    Predicted to enable type II interferon binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including Golgi to endosome transport; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K33-linked ubiquitination. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in PML body and trans-Golgi network. Is expressed in cranial ganglion; dorsal root ganglion; hindbrain; and thymus primordium. Orthologous to human KLHL20 (kelch like family member 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 5.6), limb E14.5 (RPKM 5.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl20 in Genome Data Viewer
    Location:
    1 H2.1; 1 69.75 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160915945..160959078, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161088375..161131508, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene aspartyl-tRNA synthetase 2 (mitochondrial) Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163000837-163001115 Neighboring gene STARR-positive B cell enhancer ABC_E11097 Neighboring gene centromere protein L Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163061431-163061751 Neighboring gene STARR-seq mESC enhancer starr_02813 Neighboring gene STARR-seq mESC enhancer starr_02814 Neighboring gene STARR-seq mESC enhancer starr_02815 Neighboring gene ankyrin repeat domain 45 Neighboring gene STARR-seq mESC enhancer starr_02817 Neighboring gene testis expressed 50 Neighboring gene predicted gene, 51252

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Angiopoietin-1 is regulated by miR-204 and contributes to corneal neovascularization in KLEIP-deficient mice. Kather JN, et al. Invest Ophthalmol Vis Sci, 2014 Jun 10. PMID 24917145
    2. Kelch-like ECT2-interacting protein KLEIP regulates late-stage pulmonary maturation via Hif-2α in mice. Woik N, et al. Dis Model Mech, 2014 Jun. PMID 24785085, Free PMC Article
    3. KLEIP deficiency in mice causes progressive corneal neovascular dystrophy. Hahn N, et al. Invest Ophthalmol Vis Sci, 2012 May 31. PMID 22511632
    4. Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. Liu CC, et al. Mol Cell, 2016 Jan 7. PMID 26687681
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Transgenic (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4210, MGC28950

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables type II interferon binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type II interferon binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K33-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K33-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 20
    Names
    Kelch-like ECT2 interacting protein
    kelch-like ECT2-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039482.1 → NP_001034571.1  kelch-like protein 20

      See identical proteins and their annotated locations for NP_001034571.1

      Status: VALIDATED

      Source sequence(s)
      AC138640, AK050964, AK220547, BY020135
      Consensus CDS
      CCDS35748.1
      UniProtKB/Swiss-Prot
      Q5DTH3, Q8BWA2, Q8VCK5
      Related
      ENSMUSP00000107238.2, ENSMUST00000111611.8
      Conserved Domains (3) summary
      PHA03098
      Location:58 → 581
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:350 → 394
      Kelch; KELCH repeat [structural motif]
      cd18249
      Location:40 → 167
      BTB_POZ_KLHL20_KLEIP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      160915945..160959078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164066.1 → XP_036019959.1  kelch-like protein 20 isoform X1

      Conserved Domains (2) summary
      PHA03098
      Location:27 → 284
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:53 → 97
      Kelch; KELCH repeat [structural motif]

    RNA

    1. XR_373601.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144876.2: Suppressed sequence

      Description
      NM_144876.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCK5.2 GenPept UniProtKB/Swiss-Prot:Q8VCK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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