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    Ropn1l ropporin 1-like [ Mus musculus (house mouse) ]

    Gene ID: 252967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ropn1lprovided by MGI
    Official Full Name
    ropporin 1-likeprovided by MGI
    Primary source
    MGI:MGI:2182357
    See related
    Ensembl:ENSMUSG00000022236 AllianceGenome:MGI:2182357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ASP; Akapasp
    Summary
    Predicted to enable identical protein binding activity. Acts upstream of or within flagellated sperm motility; regulation of protein phosphorylation; and sperm capacitation. Located in motile cilium. Part of radial spoke. Is expressed in several structures, including heart; liver; lung; reproductive system; and spleen. Orthologous to human ROPN1L (rhophilin associated tail protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 542.1) See more
    Orthologs
    human all
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    Genomic context

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    See Ropn1l in Genome Data Viewer
    Location:
    15 B2; 15 12.94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (31441356..31453835, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (31441210..31453689, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3134 Neighboring gene STARR-seq mESC enhancer starr_38282 Neighboring gene ankyrin repeat domain 33B Neighboring gene STARR-positive B cell enhancer ABC_E9415 Neighboring gene STARR-positive B cell enhancer ABC_E5472 Neighboring gene STARR-seq mESC enhancer starr_38287 Neighboring gene predicted gene, 41286 Neighboring gene STARR-seq mESC enhancer starr_38289 Neighboring gene STARR-positive B cell enhancer ABC_E10847 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene predicted gene, 49208 Neighboring gene membrane associated ring-CH-type finger 6 Neighboring gene STARR-seq mESC enhancer starr_38292 Neighboring gene carboxymethylenebutenolidase homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a murine testis complementary DNA encoding a homolog to human A-kinase anchoring protein-associated sperm protein. Anway MD, et al. Biol Reprod, 2002 Jun. PMID 12021058
    2. FSCB phosphorylation regulates mouse spermatozoa capacitation through suppressing SUMOylation of ROPN1/ROPN1L. Zhang X, et al. Am J Transl Res, 2016. PMID 27398160, Free PMC Article
    3. Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity. Fiedler SE, et al. Biol Reprod, 2013 Feb. PMID 23303679, Free PMC Article
    4. Loss of ASP but not ROPN1 reduces mammalian ciliary motility. Fiedler SE, et al. Cytoskeleton (Hoboken), 2012 Jan. PMID 22021175, Free PMC Article
    5. Differential requirements of IQUB for the assembly of radial spoke 1 and the motility of mouse cilia and flagella. Zhang X, et al. Cell Rep, 2022 Nov 22. PMID 36417862

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in ROPN1 and ROPN1L can cause defects in fibrous sheath integrity, sperm motility, and PKA-dependent signaling processes, leading to male infertility.
      Title: Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity.
    2. The beat frequency of cilia from mice lacking ASP is significantly slower than wild type, indicating that ASP signaling may regulate ciliary motility.
      Title: Loss of ASP but not ROPN1 reduces mammalian ciliary motility.
    3. Northern blot analysis of testis RNA from 5-, 15-, 25-, and 40-day-old mice showed expression of the ASP gene and in situ hybridization analysis localized the ASP mRNA to the germ cell compartment of the seminiferous tubules in the testis
      Title: Identification of a murine testis complementary DNA encoding a homolog to human A-kinase anchoring protein-associated sperm protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cilium movement involved in extracellular fluid movement IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in flagellated sperm motility IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sperm capacitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in 9+2 motile cilium IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ropporin-1-like protein
    Names
    A-kinase anchoring protein-associated sperm protein
    AKAP-associated sperm protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145852.2 → NP_665851.2  ropporin-1-like protein

      See identical proteins and their annotated locations for NP_665851.2

      Status: VALIDATED

      Source sequence(s)
      AK131675, AV039619
      Consensus CDS
      CCDS37053.1
      UniProtKB/Swiss-Prot
      Q6P8Z9, Q9EQ00
      Related
      ENSMUSP00000106038.2, ENSMUST00000110408.3
      Conserved Domains (1) summary
      cl02594
      Location:15 → 51
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      31441356..31453835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQ00.2 GenPept UniProtKB/Swiss-Prot:Q9EQ00

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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