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    Psmb3 proteasome (prosome, macropain) subunit, beta type 3 [ Mus musculus (house mouse) ]

    Gene ID: 26446, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psmb3provided by MGI
    Official Full Name
    proteasome (prosome, macropain) subunit, beta type 3provided by MGI
    Primary source
    MGI:MGI:1347014
    See related
    Ensembl:ENSMUSG00000069744 AllianceGenome:MGI:1347014
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C10-II
    Summary
    Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein catabolic process. Part of proteasome core complex. Is expressed in several structures, including cranial ganglion; gonad; gut; skin; and tooth. Orthologous to human PSMB3 (proteasome 20S subunit beta 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 174.6), kidney adult (RPKM 115.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Psmb3 in Genome Data Viewer
    Location:
    11 D; 11 61.07 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97594260..97604326)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97703434..97713500)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene polycomb group ring finger 2 Neighboring gene STARR-positive B cell enhancer ABC_E7051 Neighboring gene STARR-positive B cell enhancer ABC_E1430 Neighboring gene nuclear encoded tRNA asparagine 8 (anticodon GTT) Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, beta Neighboring gene microRNA 8102

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC106850

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    proteasome subunit beta type-3
    Names
    beta-3
    proteasome chain 13
    proteasome component C10-II
    proteasome subunit beta-3
    proteasome theta chain
    NP_036101.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011971.4NP_036101.1  proteasome subunit beta type-3

      See identical proteins and their annotated locations for NP_036101.1

      Status: PROVISIONAL

      Source sequence(s)
      AL596123
      Consensus CDS
      CCDS25328.1
      UniProtKB/Swiss-Prot
      Q9R1P1
      UniProtKB/TrEMBL
      Q545G0
      Related
      ENSMUSP00000099436.5, ENSMUST00000103147.5
      Conserved Domains (1) summary
      cd03759
      Location:6201
      proteasome_beta_type_3; proteasome beta type-3 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97594260..97604326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)