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    MOG1 Ran GTPase-binding protein MOG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853537, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MOG1
    Official Full Name
    Ran GTPase-binding protein MOG1
    Primary source
    SGD:S000003835
    Locus tag
    YJR074W
    See related
    AllianceGenome:SGD:S000003835; FungiDB:YJR074W; VEuPathDB:YJR074W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables small GTPase binding activity. Involved in protein import into nucleus. Located in nucleus. Orthologous to human RANGRF (RAN guanine nucleotide release factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MOG1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (573095..573751)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene GTPase NPA3 Neighboring gene bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Neighboring gene alpha-1,6-mannosyltransferase Neighboring gene septin CDC11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the PsbP protein of photosystem II from Nicotiana tabacum. Ifuku K, et al. EMBO Rep, 2004 Apr. PMID 15031714, Free PMC Article
    2. Crystallization and preliminary X-ray diffraction analysis of the Saccharomyces cerevisiae ran-binding protein Mog1p. Baker RP, et al. Acta Crystallogr D Biol Crystallogr, 2000 Feb. PMID 10666614
    3. 1.9 A resolution crystal structure of the Saccharomyces cerevisiae Ran-binding protein Mog1p. Stewart M, et al. J Mol Biol, 2000 May 26. PMID 10860733
    4. Fission yeast Mog1p homologue, which interacts with the small GTPase Ran, is required for mitosis-to-interphase transition and poly(A)(+) RNA metabolism. Tatebayashi K, et al. Genetics, 2001 Apr. PMID 11290708, Free PMC Article
    5. Yrb1p interaction with the gsp1p C terminus blocks Mog1p stimulation of GTP release from Gsp1p. Oki M, et al. J Biol Chem, 2000 Oct 20. PMID 10921930

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ran GTPase-binding protein MOG1
    NP_012608.1
    • Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      573095..573751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181732.1 → NP_012608.1  TPA: Ran GTPase-binding protein MOG1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012608.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWP4, P47123
      UniProtKB/TrEMBL
      B5VLM6, G2WH78, N1P3I6
      Conserved Domains (1) summary
      cd00224
      Location:36 → 218
      Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47123.1

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