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    HPC2 Hpc2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852516, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HPC2
    Official Full Name
    Hpc2p
    Primary source
    SGD:S000000419
    Locus tag
    YBR215W
    See related
    AllianceGenome:SGD:S000000419; FungiDB:YBR215W; VEuPathDB:YBR215W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to DNA binding activity and nucleosome binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; and transcription elongation by RNA polymerase II. Located in nucleus. Part of HIR complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HPC2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_001134.8 (653356..655317)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 Neighboring gene Sds24p Neighboring gene Ybp1p Neighboring gene Atg12p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Prochasson P, et al. Genes Dev, 2005 Nov 1. PMID 16264190, Free PMC Article
    2. Separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes. Vishnoi N, et al. Biochim Biophys Acta, 2011 Oct. PMID 21782987, Free PMC Article
    3. Uncoupling histone turnover from transcription-associated histone H3 modifications. Ferrari P, et al. Nucleic Acids Res, 2015 Apr 30. PMID 25845593, Free PMC Article
    4. Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae. Xu H, et al. Mol Cell Biol, 1992 Nov. PMID 1406694, Free PMC Article
    5. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Banumathy G, et al. Mol Cell Biol, 2009 Feb. PMID 19029251, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The histone chaperone gene HPC2 reversed the elevated manganese and phosphate of pho80 mutants by specifically repressing PHO84, encoding a metal-phosphate transporter.
      Title: Phosphate disruption and metal toxicity in Saccharomyces cerevisiae: effects of RAD23 and the histone chaperone HPC2.
    2. the separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes
      Title: Separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to nucleosome binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HIR complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HIR complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hpc2p
    NP_009774.4
    • Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      653356..655317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178563.3 → NP_009774.4  TPA: Hpc2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009774.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2TBP6, D6VQL1, Q01448
      UniProtKB/TrEMBL
      A6ZLF5
      Conserved Domains (1) summary
      pfam08729
      Location:558 → 601
      HUN; HPC2 and ubinuclein domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01448.2

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