PEX11 Pex11p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PEX11
Official Full Name: Pex11p
Primary source: SGD:S000005507
Locus tag: YOL147C
See related: AllianceGenome:SGD:S000005507; FungiDB:YOL147C; VEuPathDB:YOL147C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PMP24; PMP27
Summary: Involved in fatty acid oxidation and peroxisome fission. Located in endoplasmic reticulum and peroxisomal membrane. Part of peroxisomal importomer complex. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 14B. Orthologous to several human genes including PEX11A (peroxisomal biogenesis factor 11 alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PEX11 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (47933..48643, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lithium chloride sensitivity connects the activity of PEX11 and RIM20 to the translation of PGM2 and other mRNAs with structured 5'-UTRs.
Title: Lithium chloride sensitivity connects the activity of PEX11 and RIM20 to the translation of PGM2 and other mRNAs with structured 5'-UTRs.
Characterization of survival and stress resistance in S. cerevisiae mutants affected in peroxisome inheritance and proliferation, Deltainp1 and Deltapex11.
Title: Characterization of survival and stress resistance in S. cerevisiae mutants affected in peroxisome inheritance and proliferation, Δinp1 and Δpex11.
Data indicate that phosphorylation of peroxisomal membrane protein 27 (Pex11) may regulate peroxisomal beta-oxidation.
Title: Peroxisomal Pex11 is a pore-forming protein homologous to TRPM channels.
The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission.
Title: The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission.
Pex11 and Mdm34 physically interact and that Pex11 plays a role in establishing the contact sites between peroxisomes and mitochondria through the ERMES complex.
Title: Genome-Wide Localization Study of Yeast Pex11 Identifies Peroxisome-Mitochondria Interactions through the ERMES Complex.
ScPex11p promotes the proliferation of peroxisomes already present in the cell, ScPex25p initiates remodeling at the peroxisomal membrane and ScPex27p acts to counter this activity.
Title: A subtle interplay between three Pex11 proteins shapes de novo formation and fission of peroxisomes.
report the reversible phosphorylation of Pex11p in response to nutritional cues and delineate a mechanism for phosphorylation-dependent activation of Pex11p and peroxisome proliferation
Title: Phosphorylation-dependent activation of peroxisome proliferator protein PEX11 controls peroxisome abundance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in medium-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome fission	IEA Inferred from Electronic Annotation more info
involved_in peroxisome fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of peroxisomal importomer complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Pex11p

NP_014494.1

Peroxisomal protein required for medium-chain fatty acid oxidation; also required for peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p