Ulk2 unc-51 like autophagy activating kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ulk2provided by RGD
Official Full Name: unc-51 like autophagy activating kinase 2provided by RGD
Primary source: RGD:1310181
See related: EnsemblRapid:ENSRNOG00000002763 AllianceGenome:RGD:1310181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including axon extension; macroautophagy; and negative regulation of collateral sprouting. Predicted to act upstream of or within axon guidance; protein localization; and somatic sensory system development. Predicted to be active in autophagosome; cytosol; and phagophore assembly site membrane. Orthologous to human ULK2 (unc-51 like autophagy activating kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 159.8), Lung (RPKM 151.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (46951038..47029844, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (46451578..46530462, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (48050079..48129377, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH142524 (e-PCR)
- UniSTS:231771

RH141087 (e-PCR)
- UniSTS:223085

RH137209 (e-PCR)
- UniSTS:219297

BQ205587 (e-PCR)
- UniSTS:261290

AW532672 (e-PCR)
- UniSTS:260580

RH133544 (e-PCR)
- UniSTS:216827

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in axon extension	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of collateral sprouting	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	ISO Inferred from Sequence Orthology more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somatic sensory system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase ULK2

Names: Unc-51 like kinase 2

NP_001178574.1

EC 2.7.11.1

XP_006246559.1

EC 2.7.11.1

XP_063125079.1

EC 2.7.11.1

XP_063125080.1

EC 2.7.11.1

XP_063125081.1

EC 2.7.11.1

XP_063125082.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191645.2 → NP_001178574.1 serine/threonine-protein kinase ULK2

See identical proteins and their annotated locations for NP_001178574.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

D3Z9J7

Related

ENSRNOP00000003792.4, ENSRNOT00000003792.8

Conserved Domains (2) summary

cd14201
Location:2 → 272

STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2

pfam12063
Location:843 → 1030

DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

46951038..47029844 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269011.1 → XP_063125081.1 serine/threonine-protein kinase ULK2 isoform X4

UniProtKB/TrEMBL

A0A8I6A395

Related

ENSRNOP00000086173.1, ENSRNOT00000117957.2
XM_063269010.1 → XP_063125080.1 serine/threonine-protein kinase ULK2 isoform X3
XM_006246497.5 → XP_006246559.1 serine/threonine-protein kinase ULK2 isoform X2

UniProtKB/TrEMBL

A0A8I6ALB0

Related

ENSRNOP00000094584.1, ENSRNOT00000102303.2

Conserved Domains (3) summary

smart00220
Location:9 → 271

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14201
Location:2 → 272

STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2

pfam12063
Location:865 → 1052

DUF3543; Domain of unknown function (DUF3543)
XM_063269009.1 → XP_063125079.1 serine/threonine-protein kinase ULK2 isoform X1
XM_063269012.1 → XP_063125082.1 serine/threonine-protein kinase ULK2 isoform X5