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    Mmp23 matrix metallopeptidase 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94339, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mmp23provided by RGD
    Official Full Name
    matrix metallopeptidase 23provided by RGD
    Primary source
    RGD:620201
    See related
    EnsemblRapid:ENSRNOG00000017477 AllianceGenome:RGD:620201
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to be located in endoplasmic reticulum membrane and extracellular matrix. Predicted to be active in extracellular space. Orthologous to human MMP23B (matrix metallopeptidase 23B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 90.0), Spleen (RPKM 53.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mmp23 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171521905..171525007, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166239643..166242734, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173078811..173082834, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member E2B Neighboring gene cyclin-dependent kinase 11B Neighboring gene ribosomal protein L27A like 10 Neighboring gene MIB E3 ubiquitin protein ligase 2 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    matrix metalloproteinase-23
    Names
    MIFR
    MMP-23
    Matrix metalloproteinase 23
    metalloprotease in the female reproductive tract
    metaloprotease in the female reproductive tract

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053606.2NP_446058.1  matrix metalloproteinase-23

      See identical proteins and their annotated locations for NP_446058.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086586
      UniProtKB/Swiss-Prot
      O88272
      UniProtKB/TrEMBL
      A6IUR3
      Related
      ENSRNOP00000061528.3, ENSRNOT00000066880.5
      Conserved Domains (4) summary
      smart00254
      Location:256290
      ShKT; ShK toxin domain
      cd04278
      Location:88255
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:88255
      Peptidase_M10; Matrixin
      cl11960
      Location:314376
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171521905..171525007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110897.2XP_038966825.1  matrix metalloproteinase-23 isoform X3

      Conserved Domains (4) summary
      smart00254
      Location:218252
      ShKT; ShK toxin domain
      cd04278
      Location:88217
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cd00096
      Location:294298
      Ig; Ig strand C [structural motif]
      cl11960
      Location:276338
      Ig; Immunoglobulin domain
    2. XM_039110895.2XP_038966823.1  matrix metalloproteinase-23 isoform X1

      Conserved Domains (4) summary
      smart00254
      Location:251285
      ShKT; ShK toxin domain
      cd04278
      Location:88250
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cd00096
      Location:327331
      Ig; Ig strand C [structural motif]
      cl11960
      Location:309371
      Ig; Immunoglobulin domain
    3. XM_039110896.2XP_038966824.1  matrix metalloproteinase-23 isoform X2

      Conserved Domains (4) summary
      smart00254
      Location:245279
      ShKT; ShK toxin domain
      cd04278
      Location:88244
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      cd00096
      Location:321325
      Ig; Ig strand C [structural motif]
      cl11960
      Location:303365
      Ig; Immunoglobulin domain
    4. XM_017593671.3XP_017449160.1  matrix metalloproteinase-23 isoform X4