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    Acss2 acyl-CoA synthetase short-chain family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311569, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acss2provided by RGD
    Official Full Name
    acyl-CoA synthetase short-chain family member 2provided by RGD
    Primary source
    RGD:1305489
    See related
    EnsemblRapid:ENSRNOG00000018755 AllianceGenome:RGD:1305489
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acas2
    Summary
    Enables acetate-CoA ligase activity. Involved in acetate biosynthetic process and propionate biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 882.3), Liver (RPKM 286.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acss2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164464124..164507607)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (144003808..144047452)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151032925..151075856)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene gamma-glutamyltransferase 7 Neighboring gene small nucleolar RNA SNORA18 Neighboring gene glutathione synthetase Neighboring gene myosin heavy chain 7B Neighboring gene microRNA 499a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans. Männistö VT, et al. Liver Int, 2015 Jul. PMID 25533197
    2. De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery. Garrido-Sánchez L, et al. PLoS One, 2012. PMID 22384010, Free PMC Article
    3. SCFAs Ameliorate Chronic Postsurgical Pain-Related Cognition Dysfunction via the ACSS2-HDAC2 Axis in Rats. Li Z, et al. Mol Neurobiol, 2022 Oct. PMID 35902549, Free PMC Article
    4. ACSS2 gene variant associated with cleft lip and palate in two independent Hispanic populations. Dodhia S, et al. Laryngoscope, 2017 Oct. PMID 28543373, Free PMC Article
    5. Using Whole Exome Sequencing to Identify Candidate Genes With Rare Variants In Nonsyndromic Cleft Lip and Palate. Aylward A, et al. Genet Epidemiol, 2016 Jul. PMID 27229527, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCFAs Ameliorate Chronic Postsurgical Pain-Related Cognition Dysfunction via the ACSS2-HDAC2 Axis in Rats.
      Title: SCFAs Ameliorate Chronic Postsurgical Pain-Related Cognition Dysfunction via the ACSS2-HDAC2 Axis in Rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables propionate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in acetyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acetyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-term memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in propionate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acetyl-coenzyme A synthetase, cytoplasmic
    Names
    acetyl-Coenzyme A synthetase 2 (ADP forming)
    NP_001101263.1
    XP_006235383.3
    XP_038961004.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107793.1 → NP_001101263.1  acetyl-coenzyme A synthetase, cytoplasmic

      See identical proteins and their annotated locations for NP_001101263.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474050
      UniProtKB/TrEMBL
      A6KI41, B1WC11
      Related
      ENSRNOP00000059987.3, ENSRNOT00000064013.3
      Conserved Domains (1) summary
      cd05966
      Location:45 → 685
      ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      164464124..164507607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105076.2 → XP_038961004.1  acetyl-coenzyme A synthetase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      B1WC11
      Conserved Domains (1) summary
      cd05966
      Location:1 → 603
      ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)

    2. XM_006235321.5 → XP_006235383.3  acetyl-coenzyme A synthetase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJ11, G3V9U0
      Related
      ENSRNOP00000090627.2, ENSRNOT00000107324.2
      Conserved Domains (1) summary
      cd05966
      Location:89 → 742
      ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    Nucleotide Protein Strain
    Heading Accession and Version

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