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    Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29738, updated on 3-Dec-2024

    Summary

    Official Symbol
    Kcnab2provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily A regulatory beta subunit 2provided by RGD
    Primary source
    RGD:61828
    See related
    EnsemblRapid:ENSRNOG00000011550 AllianceGenome:RGD:61828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including NADPH oxidation; myoblast differentiation; and regulation of protein localization to cell surface. Located in several cellular components, including axon; cytoplasmic side of plasma membrane; and microtubule. Part of potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 249.8), Thymus (RPKM 121.4) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kcnab2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (168182228..168270760, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162899511..162988057, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169570327..169658875, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103139 Neighboring gene ribosomal protein L22 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene small ribosomal subunit protein eS27-like Neighboring gene nephrocystin 4 Neighboring gene uncharacterized LOC134479049 Neighboring gene uncharacterized LOC102549399

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aldo-keto reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylglyoxal reductase (NADPH) (acetol producing) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axon initial segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in juxtaparanode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in juxtaparanode region of axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in pinceau fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    voltage-gated potassium channel subunit beta-2
    Names
    K(+) channel subunit beta-2
    kv-beta-2
    potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2
    potassium channel, voltage gated subfamily A regulatory beta subunit 2
    potassium voltage-gated channel, shaker-related subfamily, beta member 2
    NP_059000.1
    XP_017448703.1
    XP_017448704.1
    XP_038965314.1
    XP_063143337.1
    XP_063143338.1
    XP_063143339.1
    XP_063143340.1
    XP_063143341.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429742.1NP_001416671.1  voltage-gated potassium channel subunit beta-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K670
    2. NM_001429743.1NP_001416672.1  voltage-gated potassium channel subunit beta-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K670
    3. NM_001429744.1NP_001416673.1  voltage-gated potassium channel subunit beta-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZVX6, A0A8L2Q7L3
    4. NM_001429745.1NP_001416674.1  voltage-gated potassium channel subunit beta-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZVX6
    5. NM_001429746.1NP_001416675.1  voltage-gated potassium channel subunit beta-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P62483
      UniProtKB/TrEMBL
      A0A8I5ZVX6, A6IUI6
    6. NM_001429747.1NP_001416676.1  voltage-gated potassium channel subunit beta-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZVX6, A0A8I6GCY0
    7. NM_001429748.1NP_001416677.1  voltage-gated potassium channel subunit beta-2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZVX6, A0A8I6GCY0
    8. NM_017304.3NP_059000.1  voltage-gated potassium channel subunit beta-2 isoform 5

      See identical proteins and their annotated locations for NP_059000.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P62483
      UniProtKB/TrEMBL
      A0A8I5ZVX6, A6IUI6
      Related
      ENSRNOP00000085478.2, ENSRNOT00000101700.2
      Conserved Domains (1) summary
      cd19141
      Location:38347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      168182228..168270760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593214.3XP_017448703.1  voltage-gated potassium channel subunit beta-2 isoform X1

      Related
      ENSRNOP00000015840.3, ENSRNOT00000015840.5
      Conserved Domains (1) summary
      cd19141
      Location:38363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    2. XM_039109386.2XP_038965314.1  voltage-gated potassium channel subunit beta-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZVX6
      Conserved Domains (1) summary
      cl00470
      Location:1296
      AKR_SF; Aldo-keto reductase (AKR) superfamily
    3. XM_063287270.1XP_063143340.1  voltage-gated potassium channel subunit beta-2 isoform X5

      Related
      ENSRNOP00000082892.2, ENSRNOT00000111948.2
    4. XM_063287268.1XP_063143338.1  voltage-gated potassium channel subunit beta-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVX6
      Related
      ENSRNOP00000081886.1, ENSRNOT00000113173.2
    5. XM_063287269.1XP_063143339.1  voltage-gated potassium channel subunit beta-2 isoform X4

    6. XM_063287267.1XP_063143337.1  voltage-gated potassium channel subunit beta-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVX6
    7. XM_017593215.3XP_017448704.1  voltage-gated potassium channel subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVX6, A0A8L2Q7L3
      Conserved Domains (1) summary
      cd19141
      Location:38363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    8. XM_063287271.1XP_063143341.1  voltage-gated potassium channel subunit beta-2 isoform X7