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    TRIM10 tripartite motif containing 10 [ Homo sapiens (human) ]

    Gene ID: 10107, updated on 4-Jan-2025

    Summary

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    Official Symbol
    TRIM10provided by HGNC
    Official Full Name
    tripartite motif containing 10provided by HGNC
    Primary source
    HGNC:HGNC:10072
    See related
    Ensembl:ENSG00000204613 MIM:605701; AllianceGenome:HGNC:10072
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF9; HERF1; RFB30
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 6.5), kidney (RPKM 1.8) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIM10 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30151943..30164009, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30016218..30028317, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30119720..30128988, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene tripartite motif containing 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30139523-30140072 Neighboring gene tripartite motif containing 15 Neighboring gene MPRA-validated peak5749 silencer Neighboring gene PAIP1 pseudogene 1 Neighboring gene tripartite motif containing 26 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:30168993-30169678 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:30169679-30170363 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30175183-30176130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30181514-30182402 Neighboring gene tripartite motif containing 26B, pseudogene Neighboring gene HLA complex group 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning, structural analysis, and mapping of the B30 and B7 multigenic families to the major histocompatibility complex (MHC) and other chromosomal regions. Henry J, et al. Immunogenetics, 1997. PMID 9271628
    2. Oncogenic gene TRIM10 confers resistance to cisplatin in osteosarcoma cells and activates the NF-κB signaling pathway. Xi X, et al. Cell Biol Int, 2021 Jan. PMID 32997424
    3. Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. Goei VL, et al. Am J Hum Genet, 1994 Feb. PMID 8304341, Free PMC Article
    4. TRIM10 binds to IFN-α/β receptor 1 to negatively regulate type I IFN signal transduction. Guo M, et al. Eur J Immunol, 2021 Jul. PMID 33811647
    5. Molecular cloning of testis-abundant finger Protein/Ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC. Orimo A, et al. Biochem Biophys Res Commun, 2000 Sep 16. PMID 11006080

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM10 binds to IFN-alpha/beta receptor 1 to negatively regulate type I IFN signal transduction.
      Title: TRIM10 binds to IFN-α/β receptor 1 to negatively regulate type I IFN signal transduction.
    2. Oncogenic gene TRIM10 confers resistance to cisplatin in osteosarcoma cells and activates the NF-kappaB signaling pathway.
      Title: Oncogenic gene TRIM10 confers resistance to cisplatin in osteosarcoma cells and activates the NF-κB signaling pathway.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variation and the control of HIV-1 in humans.
    EBI GWAS Catalog
    Genome-wide association study of proneness to anger.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141979

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 10
    Names
    B30-RING finger protein
    Zn-finger protein
    hematopoietic RING finger 1
    ring finger protein 9
    tripartite motif protein 10

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006778.4 → NP_006769.2  tripartite motif-containing protein 10 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1, which has a distinct C-terminus and is 86 aa longer than isoform 2.
      Source sequence(s)
      AL360163, AL669914, BC093926
      Consensus CDS
      CCDS34375.1
      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
      Related
      ENSP00000397073.2, ENST00000449742.7
      Conserved Domains (4) summary
      smart00336
      Location:94 → 135
      BBOX; B-Box-type zinc finger
      cd15827
      Location:309 → 480
      SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
      cl17238
      Location:16 → 60
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl23765
      Location:143 → 217
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_052828.3 → NP_439893.2  tripartite motif-containing protein 10 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that results in the introduction of a 539 nt intron between a 3' penultimate and 3' terminal exon, compared to the 3' terminal exon of variant 1. This results in a frameshift and introduction of a novel stop codon. Isoform 2 has a distinct C-terminus and is 86 aa shorter than isoform 1.
      Source sequence(s)
      AL360163, AL669914, BC093926
      Consensus CDS
      CCDS4676.1
      UniProtKB/TrEMBL
      A0A1U9X8M5, A0A1U9X8N7
      Related
      ENSP00000365894.3, ENST00000376704.3
      Conserved Domains (4) summary
      smart00336
      Location:94 → 135
      BBOX; B-Box-type zinc finger
      cd16593
      Location:13 → 61
      RING-HC_TRIM10_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 10 (TRIM10) and similar proteins
      cl02614
      Location:309 → 368
      SPRY; SPRY domain
      cl25407
      Location:143 → 217
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      30151943..30164009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418051.1 → XP_047274007.1  tripartite motif-containing protein 10 isoform X1

    2. XM_047418052.1 → XP_047274008.1  tripartite motif-containing protein 10 isoform X1

    3. XM_011514221.2 → XP_011512523.1  tripartite motif-containing protein 10 isoform X1

      Conserved Domains (4) summary
      smart00336
      Location:112 → 153
      BBOX; B-Box-type zinc finger
      cd15827
      Location:327 → 498
      SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
      cl17238
      Location:41 → 78
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl23765
      Location:161 → 235
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    4. XM_011514223.3 → XP_011512525.1  tripartite motif-containing protein 10 isoform X1

      Conserved Domains (4) summary
      smart00336
      Location:112 → 153
      BBOX; B-Box-type zinc finger
      cd15827
      Location:327 → 498
      SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
      cl17238
      Location:41 → 78
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl23765
      Location:161 → 235
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    5. XM_011514222.3 → XP_011512524.1  tripartite motif-containing protein 10 isoform X1

      Conserved Domains (4) summary
      smart00336
      Location:112 → 153
      BBOX; B-Box-type zinc finger
      cd15827
      Location:327 → 498
      SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
      cl17238
      Location:41 → 78
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl23765
      Location:161 → 235
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    6. XM_047418053.1 → XP_047274009.1  tripartite motif-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8N7

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1410039..1421508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328439.1 → XP_054184414.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    2. XM_054328440.1 → XP_054184415.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    3. XM_054328441.1 → XP_054184416.1  tripartite motif-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8N7

    4. XM_054328442.1 → XP_054184417.1  tripartite motif-containing protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A1U9X8M5, A0A1U9X8N7

    5. XM_054328438.1 → XP_054184413.1  tripartite motif-containing protein 10 isoform X1

    6. XM_054328437.1 → XP_054184412.1  tripartite motif-containing protein 10 isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1631751..1643791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329718.1 → XP_054185693.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    2. XM_054329716.1 → XP_054185691.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    3. XM_054329717.1 → XP_054185692.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      1407860..1419329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330211.1 → XP_054186186.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    2. XM_054330212.1 → XP_054186187.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    3. XM_054330213.1 → XP_054186188.1  tripartite motif-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8N7

    4. XM_054330214.1 → XP_054186189.1  tripartite motif-containing protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A1U9X8M5, A0A1U9X8N7

    5. XM_054330210.1 → XP_054186185.1  tripartite motif-containing protein 10 isoform X1

    6. XM_054330209.1 → XP_054186184.1  tripartite motif-containing protein 10 isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      1462665..1474130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330506.1 → XP_054186481.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    2. XM_054330507.1 → XP_054186482.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    3. XM_054330505.1 → XP_054186480.1  tripartite motif-containing protein 10 isoform X1

    4. XM_054330504.1 → XP_054186479.1  tripartite motif-containing protein 10 isoform X1

    5. XM_054330508.1 → XP_054186483.1  tripartite motif-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8N7

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      1496018..1508131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330755.1 → XP_054186730.1  tripartite motif-containing protein 10 isoform X1

    2. XM_054330756.1 → XP_054186731.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    3. XM_054330754.1 → XP_054186729.1  tripartite motif-containing protein 10 isoform X1

    4. XM_054330757.1 → XP_054186732.1  tripartite motif-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8N7

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      1407072..1418556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330985.1 → XP_054186960.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    2. XM_054330988.1 → XP_054186963.1  tripartite motif-containing protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A1U9X8M5, A0A1U9X8N7

    3. XM_054330986.1 → XP_054186961.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    4. XM_054330987.1 → XP_054186962.1  tripartite motif-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8N7

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      1450868..1462134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331268.1 → XP_054187243.1  tripartite motif-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8N7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      30016218..30028317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353995.1 → XP_054209970.1  tripartite motif-containing protein 10 isoform X1

    2. XM_054353996.1 → XP_054209971.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    3. XM_054353997.1 → XP_054209972.1  tripartite motif-containing protein 10 isoform X3

      UniProtKB/Swiss-Prot
      A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

    4. XM_054353999.1 → XP_054209974.1  tripartite motif-containing protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A1U9X8M5, A0A1U9X8N7

    5. XM_054353994.1 → XP_054209969.1  tripartite motif-containing protein 10 isoform X1

    6. XM_054353993.1 → XP_054209968.1  tripartite motif-containing protein 10 isoform X1

    7. XM_054353998.1 → XP_054209973.1  tripartite motif-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A1U9X8N7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UDY6.3 GenPept UniProtKB/Swiss-Prot:Q9UDY6

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