for foraging [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: forprovided by FlyBase
Official Full Name: foragingprovided by FlyBase
Primary source: FLYBASE:FBgn0000721
Locus tag: Dmel_CG10033
See related: AllianceGenome:FB:FBgn0000721
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 142251_at; anon-WO0140519.260; anon-WO02059370.47; BcDNA:GM08338; CG10033; dg2; Dg2; DG2; Dmel\CG10033; For; FOR/PKG; l(2)06860; PKG; Pkg2; PKG2; Pkg24A
Summary: Enables cGMP-dependent protein kinase activity. Involved in several processes, including larval feeding behavior; learning or memory; and positive regulation of Toll signaling pathway. Located in cytosol and plasma membrane. Is expressed in several structures, including embryonic/larval midgut cell; ganglia; gut section; head epidermis primordium; and synaptic neuropil subdomain. Used to study epilepsy. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 24A2-24A4; 2-10 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3622074..3656953, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3622074..3656953, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Drosophila melanogaster foraging gene affects social networks.
Title: The Drosophila melanogaster foraging gene affects social networks.
The foraging gene affects alcohol sensitivity, metabolism and memory in Drosophila.
Title: The foraging gene affects alcohol sensitivity, metabolism and memory in Drosophila.
Expression of the foraging gene in adult Drosophila melanogaster.
Title: Expression of the foraging gene in adult Drosophila melanogaster.
A cGMP-dependent protein kinase, encoded by the Drosophila foraging gene, regulates neurotransmission through changes in synaptic structure and function.
Title: A cGMP-dependent protein kinase, encoded by the Drosophila foraging gene, regulates neurotransmission through changes in synaptic structure and function.
The Drosophila foraging gene plays a vital role at the start of metamorphosis for subsequent adult emergence.
Title: The Drosophila foraging gene plays a vital role at the start of metamorphosis for subsequent adult emergence.
Environmental influences on for-mediated oviposition decisions in Drosophila melanogaster.
Title: Environmental influences on for-mediated oviposition decisions in Drosophila melanogaster.
Drosophila melanogaster foraging regulates a nociceptive-like escape behavior through a developmentally plastic sensory circuit.
Title: Drosophila melanogaster foraging regulates a nociceptive-like escape behavior through a developmentally plastic sensory circuit.
FOR plays a critical role in coupling synaptic vesicle exocytosis and endocytosis, thereby balancing these two components to maintain sustained neurotransmission.
Title: Distinct functions of a cGMP-dependent protein kinase in nerve terminal growth and synaptic vesicle cycling.
Polymorphism in the foraging gene confers protection during low oxygen stress at the expense of longevity and a decline in locomotor activity with age in D. melanogaster, which suggests a novel role for the PKG pathway in healthy aging and senescence.
Title: Natural polymorphism in protein kinase G modulates functional senescence in Drosophilamelanogaster.
Our results refine the spatial expression responsible for foraging's associated phenotypes, as well as the sub-regions of the locus responsible for their expression. foraging's pleiotropy arises at least in part from the individual contributions of its four promoters
Title: Pleiotropy of the Drosophila melanogaster foraging gene on larval feeding-related traits.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cGMP-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cGMP-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables cGMP-dependent protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in feeding behavior	TAS Traceable Author Statement more info	PubMed
involved_in habituation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	TAS Traceable Author Statement more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Toll signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to food	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to sucrose	IDA Inferred from Direct Assay more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: foraging

Names: CG10033-PA; CG10033-PC; CG10033-PD; CG10033-PE; CG10033-PG; CG10033-PH; CG10033-PI; CG10033-PJ; CG10033-PK; CG10033-PL; CG10033-PM; CG10033-PN; CG10033-PO; for-PA; for-PC; for-PD; for-PE; for-PG; for-PH; for-PI; for-PJ; for-PK; for-PL; for-PM; for-PN; for-PO

NP_001014464.1

EC 2.7.11.1

EC 2.7.11.12

NP_001162858.1

EC 2.7.11.1

EC 2.7.11.12

NP_001334731.1

EC 2.7.11.1

EC 2.7.11.12

NP_001356892.1

EC 2.7.11.1

EC 2.7.11.12

NP_001356896.1

EC 2.7.11.1

EC 2.7.11.12

NP_001356955.1

EC 2.7.11.1

EC 2.7.11.12

NP_477487.1

EC 2.7.11.1

EC 2.7.11.12

NP_477489.1

EC 2.7.11.1

EC 2.7.11.12

NP_477490.1

EC 2.7.11.1

EC 2.7.11.12

NP_599146.1

EC 2.7.11.1

EC 2.7.11.12

NP_995626.1

EC 2.7.11.1

EC 2.7.11.12

NP_995628.1

EC 2.7.11.1

EC 2.7.11.12

NP_995629.1

EC 2.7.11.1

EC 2.7.11.12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

3622074..3656953 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_205904.2 → NP_995626.1 foraging, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995626.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V042, Q03043, Q24304, Q9I7Q1, Q9VQT2

UniProtKB/TrEMBL

E1U3G1

Conserved Domains (5) summary

cd12085
Location:385 → 432

DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha

smart00220
Location:778 → 1036

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:632 → 753

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:638 → 754

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:783 → 1043

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_001369953.1 → NP_001356892.1 foraging, isoform M [Drosophila melanogaster]

Status: REVIEWED

Conserved Domains (2) summary

cd00038
Location:118 → 234

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:263 → 523

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_058139.4 → NP_477487.1 foraging, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477487.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V042, Q03043, Q24304, Q9I7Q1, Q9VQT2

UniProtKB/TrEMBL

E1U3G1

Related

FBpp0088350

Conserved Domains (5) summary

cd12085
Location:385 → 432

DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha

smart00220
Location:778 → 1036

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:632 → 753

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:638 → 754

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:783 → 1043

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_001369954.1 → NP_001356896.1 foraging, isoform N [Drosophila melanogaster]

Status: REVIEWED

Conserved Domains (2) summary

cd00038
Location:118 → 234

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:263 → 523

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_205906.2 → NP_995628.1 foraging, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995628.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V042, Q03043, Q24304, Q9I7Q1, Q9VQT2

UniProtKB/TrEMBL

E1U3G1

Conserved Domains (5) summary

cd12085
Location:385 → 432

DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha

smart00220
Location:778 → 1036

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:632 → 753

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:638 → 754

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:783 → 1043

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_001347740.1 → NP_001334731.1 foraging, isoform L [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1W5Q0S1, E1U3F9
NM_001369955.1 → NP_001356955.1 foraging, isoform O [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4D6K344

Conserved Domains (2) summary

cd00038
Location:21 → 137

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:166 → 426

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_001014464.2 → NP_001014464.1 foraging, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014464.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V044, A4V046, P32023, Q0E8U1, Q24302, Q24303, Q9I7Q0, Q9I7Q2

UniProtKB/TrEMBL

E1U3G0

Conserved Domains (4) summary

smart00220
Location:624 → 882

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:478 → 599

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:484 → 600

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:629 → 889

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_058141.4 → NP_477489.1 foraging, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477489.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHR9, E1U3G2

Related

FBpp0088353

Conserved Domains (4) summary

smart00220
Location:584 → 842

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:438 → 559

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:444 → 560

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:589 → 849

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_205907.2 → NP_995629.1 foraging, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995629.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHR9, E1U3G2

Conserved Domains (4) summary

smart00220
Location:584 → 842

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:438 → 559

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:444 → 560

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:589 → 849

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_134319.4 → NP_599146.1 foraging, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599146.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHR9, E1U3G2

Related

FBpp0088354

Conserved Domains (4) summary

smart00220
Location:584 → 842

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:438 → 559

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:444 → 560

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:589 → 849

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_058142.4 → NP_477490.1 foraging, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477490.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V044, A4V046, P32023, Q0E8U1, Q24302, Q24303, Q9I7Q0, Q9I7Q2

UniProtKB/TrEMBL

E1U3G0

Related

FBpp0088352

Conserved Domains (4) summary

smart00220
Location:624 → 882

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:478 → 599

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:484 → 600

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:629 → 889

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_001169387.2 → NP_001162858.1 foraging, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162858.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHR9, E1U3G2

Conserved Domains (4) summary

smart00220
Location:584 → 842

S_TKc; Serine/Threonine protein kinases, catalytic domain

COG0664
Location:438 → 559

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:444 → 560

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:589 → 849

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)