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    Dscc1 DNA replication and sister chromatid cohesion 1 [ Mus musculus (house mouse) ]

    Gene ID: 72107, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dscc1provided by MGI
    Official Full Name
    DNA replication and sister chromatid cohesion 1provided by MGI
    Primary source
    MGI:MGI:1919357
    See related
    Ensembl:ENSMUSG00000022422 AllianceGenome:MGI:1919357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dcc1; 2010006I05Rik; 2600005O03Rik
    Summary
    Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in maintenance of mitotic sister chromatid cohesion; positive regulation of DNA-directed DNA polymerase activity; and post-translational protein acetylation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in chromosome, centromeric region. Is expressed in brain. Orthologous to human DSCC1 (DNA replication and sister chromatid cohesion 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14 (RPKM 4.6), CNS E11.5 (RPKM 4.2) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dscc1 in Genome Data Viewer
    Location:
    15 D1; 15 21.96 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (54939497..54953887, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (55076101..55090491, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2491 Neighboring gene TATA-box binding protein associated factor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr15:54903568-54903869 Neighboring gene predicted gene, 41325 Neighboring gene STARR-positive B cell enhancer ABC_E3139 Neighboring gene predicted gene 9920 Neighboring gene DEP domain containing MTOR-interacting protein Neighboring gene predicted gene, 26296

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An atlas of genetic influences on osteoporosis in humans and mice. Morris JA, et al. Nat Genet, 2019 Feb. PMID 30598549, Free PMC Article
    2. Keratin 13 deficiency causes white sponge nevus in mice. Simonson L, et al. Dev Biol, 2020 Dec 1. PMID 32758484, Free PMC Article
    3. A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5). Geyer SH, et al. J Anat, 2017 May. PMID 28185240, Free PMC Article
    4. Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Ulmke PA, et al. Stem Cell Reports, 2021 Apr 13. PMID 33798452, Free PMC Article
    5. Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Machold R, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21440680, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151210, MGC151212

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to DNA clamp loader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of mitotic sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in post-translational protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ctf18 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ctf18 RFC-like complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sister chromatid cohesion protein DCC1
    Names
    defective in sister chromatid cohesion 1 homolog
    defective in sister chromatid cohesion protein 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355594.1 → NP_001342523.1  sister chromatid cohesion protein DCC1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC137950
      Consensus CDS
      CCDS88764.1
      UniProtKB/TrEMBL
      D3YVY9
      Related
      ENSMUSP00000105860.2, ENSMUST00000110231.2
      Conserved Domains (1) summary
      pfam09724
      Location:49 → 426
      DUF2036; Uncharacterized conserved protein (DUF2036)

    2. NM_183089.3 → NP_898912.2  sister chromatid cohesion protein DCC1 isoform 2

      See identical proteins and their annotated locations for NP_898912.2

      Status: VALIDATED

      Source sequence(s)
      AC137950
      Consensus CDS
      CCDS27473.1
      UniProtKB/Swiss-Prot
      Q14AI0, Q4FZL5
      Related
      ENSMUSP00000023059.7, ENSMUST00000023059.13
      Conserved Domains (1) summary
      pfam09724
      Location:49 → 363
      DUF2036; Uncharacterized conserved protein (DUF2036)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      54939497..54953887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14AI0.1 GenPept UniProtKB/Swiss-Prot:Q14AI0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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