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    Pkd2 polycystin 2, transient receptor potential cation channel [ Mus musculus (house mouse) ]

    Gene ID: 18764, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pkd2provided by MGI
    Official Full Name
    polycystin 2, transient receptor potential cation channelprovided by MGI
    Primary source
    MGI:MGI:1099818
    See related
    Ensembl:ENSMUSG00000034462 AllianceGenome:MGI:1099818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PC2; TRPP2; C030034P18Rik
    Summary
    Enables several functions, including ATPase binding activity; identical protein binding activity; and monoatomic cation channel activity. Involved in several processes, including detection of nodal flow; monoatomic cation transmembrane transport; and positive regulation of biosynthetic process. Acts upstream of or within several processes, including intracellular calcium ion homeostasis; liver development; and negative regulation of ryanodine-sensitive calcium-release channel activity. Located in several cellular components, including basal cortex; ciliary membrane; and microtubule cytoskeleton. Part of polycystin complex. Colocalizes with cell-cell junction. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study autosomal dominant polycystic kidney disease and polycystic kidney disease 2. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Orthologous to human PKD2 (polycystin 2, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 13.0), bladder adult (RPKM 11.6) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pkd2 in Genome Data Viewer
    Location:
    5 E5; 5 50.68 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (104599379..104653685)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (104453982..104505819)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54330 Neighboring gene matrix extracellular phosphoglycoprotein with ASARM motif (bone) Neighboring gene Spp1 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_13825 Neighboring gene secreted phosphoprotein 1 Neighboring gene STARR-seq mESC enhancer starr_13829 Neighboring gene STARR-seq mESC enhancer starr_13830 Neighboring gene THO complex subunit 2-like Neighboring gene STARR-positive B cell enhancer ABC_E4770 Neighboring gene zinc finger protein 33B Neighboring gene predicted gene, 54331

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables HLH domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables HLH domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-induced calcium release activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-induced calcium release activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables muscle alpha-actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables muscle alpha-actinin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables muscle alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables outward rectifier potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphoprotein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription regulator inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aorta development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell surface receptor signaling pathway via JAK-STAT EXP
    Inferred from Experiment
    more info
    PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to fluid shear stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrostatic pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrostatic pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cilium organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within detection of mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of nodal flow IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of liver left/right asymmetry IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in determination of liver left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heart looping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inorganic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within liver development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mesonephric duct development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric S-shaped body morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric ascending thin limb development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric cortical collecting duct development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric distal tubule development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric mesenchyme development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric part of ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric smooth muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of ryanodine-sensitive calcium-release channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neural tube development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in placenta blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein tetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of calcium ion import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in renal tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cation channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cation channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lumenal side of endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lumenal side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in migrasome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in migrasome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of polycystin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of polycystin complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of polycystin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    polycystin-2
    Names
    polycystic kidney disease 2 protein homolog
    transient receptor potential cation channel subfamily P member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008861.3NP_032887.3  polycystin-2

      See identical proteins and their annotated locations for NP_032887.3

      Status: VALIDATED

      Source sequence(s)
      AC123687, AK053502, AV517098, BU705556, CX566027
      Consensus CDS
      CCDS19487.1
      UniProtKB/Swiss-Prot
      C0KJK2, E9Q4F6, E9QQA3, O35245, Q8BPR6, Q9ES37, Q9QWP0, Q9Z193, Q9Z194
      Related
      ENSMUSP00000084041.4, ENSMUST00000086831.4
      Conserved Domains (2) summary
      pfam08016
      Location:265685
      PKD_channel; Polycystin cation channel
      cl08302
      Location:730776
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      104599379..104653685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534815.5XP_006534878.1  polycystin-2 isoform X1

      UniProtKB/Swiss-Prot
      O35245
      Conserved Domains (3) summary
      pfam08016
      Location:266629
      PKD_channel; Polycystin cation channel
      pfam18109
      Location:776810
      Fer4_24; Ferredoxin I 4Fe-4S cluster domain
      cl08302
      Location:674720
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RNA

    1. XR_001784633.3 RNA Sequence

    2. XR_003955591.2 RNA Sequence