sotv sister of tout-velu [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sotvprovided by FlyBase
Official Full Name: sister of tout-veluprovided by FlyBase
Primary source: FLYBASE:FBgn0029175
Locus tag: Dmel_CG8433
See related: AllianceGenome:FB:FBgn0029175
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH02288; CG33038; CG8433; dExt2; DExt2; DEXT2; Dmel\CG8433; Ext2; EXT2; Sotv
Summary: Enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process and heparin biosynthetic process. Located in Golgi apparatus and endoplasmic reticulum. Part of EXT1-EXT2 complex. Is expressed in adult ensheathing glial cell and organism. Orthologous to human EXT2 (exostosin glycosyltransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 52E11-52E11; 2-77 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16145904..16148719, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12033409..12036224, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that all three Drosophila EXT proteins -- tout-velu, brother of tout-velu, and sister of tout-velu -- are required for the biosynthesis of heparan sulfate proteoglycans, and for the gradient formation of morphogens.
Title: Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycosaminoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of EXT1-EXT2 complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sister of tout-velu

Names: CG8433-PB; Ext2; sister of ttv; sister-of-tout-velu; sotv-PB

NP_725536.1

EC 2.4.-.-

EC 2.4.1.224

EC 2.4.1.225

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16145904..16148719 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166150.3 → NP_725536.1 sister of tout-velu [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725536.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZJ2, Q9Y169

Conserved Domains (2) summary

pfam03016
Location:105 → 380

Exostosin; Exostosin family

pfam09258
Location:455 → 689

Glyco_transf_64; Glycosyl transferase family 64 domain