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    Scp2 sterol carrier protein 2, liver [ Mus musculus (house mouse) ]

    Gene ID: 20280, updated on 9-Dec-2024

    Summary

    Official Symbol
    Scp2provided by MGI
    Official Full Name
    sterol carrier protein 2, liverprovided by MGI
    Primary source
    MGI:MGI:98254
    See related
    Ensembl:ENSMUSG00000028603 AllianceGenome:MGI:98254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCPX; SCP-2; SCP-X; NSL-TP; ns-LTP
    Summary
    Predicted to enable several functions, including C-acyltransferase activity; anion binding activity; and lipid transfer activity. Involved in regulation of phospholipid biosynthetic process. Located in endoplasmic reticulum; mitochondrion; and peroxisome. Is expressed in several structures, including central nervous system; hair follicle; intestine; liver; and retina layer. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 155.8), liver E18 (RPKM 130.2) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Scp2 in Genome Data Viewer
    Location:
    4 C7; 4 50.2 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107901027..108002168, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108043830..108144971, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:107690940-107691141 Neighboring gene podocan Neighboring gene predicted gene, 23354 Neighboring gene STARR-positive B cell enhancer ABC_E9592 Neighboring gene STARR-seq mESC enhancer starr_11029 Neighboring gene microRNA 6397 Neighboring gene STARR-seq mESC enhancer starr_11030 Neighboring gene STARR-seq mESC enhancer starr_11031 Neighboring gene predicted gene, 54248 Neighboring gene STARR-seq mESC enhancer starr_11032 Neighboring gene enoyl Coenzyme A hydratase domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetyl-CoA C-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyl-CoA C-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables acetyl-CoA C-myristoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyl-CoA C-myristoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cholesterol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain fatty acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oleic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylethanolamine transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables propanoyl-CoA C-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables propionyl-CoA C2-trimethyltridecanoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables propionyl-CoA C2-trimethyltridecanoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bile acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inositol trisphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid hydroperoxide transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid hydroperoxide transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in progesterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phospholipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sterol transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in peroxisomal matrix TAS
    Traceable Author Statement
    more info
     
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sterol carrier protein 2
    Names
    SCP-2/3-oxoacyl-CoA thiolase
    SCP-2/thiolase
    SCP-chi
    acetyl-CoA C-myristoyltransferase
    non-specific lipid-transfer protein
    nonspecific lipid transfer protein
    propanoyl-CoA C-acyltransferase
    sterol carrier protein X
    straight-chain acyl-CoA oxidase
    NP_035457.1
    XP_011238779.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011327.4NP_035457.1  sterol carrier protein 2

      See identical proteins and their annotated locations for NP_035457.1

      Status: VALIDATED

      Source sequence(s)
      AK004860, BB774576, CJ238474, DN176201, M91458
      Consensus CDS
      CCDS18446.1
      UniProtKB/Swiss-Prot
      A2APS2, A2APS3, P32020, Q9DBM7
      Related
      ENSMUSP00000030340.9, ENSMUST00000030340.15
      Conserved Domains (3) summary
      PRK08256
      Location:12404
      PRK08256; lipid-transfer protein; Provisional
      cd00826
      Location:17403
      nondecarbox_cond_enzymes; nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 ...
      pfam02036
      Location:452538
      SCP2; SCP-2 sterol transfer family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      107901027..108002168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240477.2XP_011238779.1  sterol carrier protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011238779.1

      Conserved Domains (2) summary
      PRK08256
      Location:8388
      PRK08256; lipid-transfer protein; Provisional
      pfam02036
      Location:436522
      SCP2; SCP-2 sterol transfer family