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    Vamp1 vesicle-associated membrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 22317, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vamp1provided by MGI
    Official Full Name
    vesicle-associated membrane protein 1provided by MGI
    Primary source
    MGI:MGI:1313276
    See related
    Ensembl:ENSMUSG00000030337 AllianceGenome:MGI:1313276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    lew; Syb1; Syb-1; VAMP-1
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in SNARE complex assembly; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle priming. Located in cell surface. Is active in glutamatergic synapse and neuromuscular junction. Is expressed in brain; cerebellum molecular layer; and ventral tegmental area. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to human VAMP1 (vesicle associated membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 144.0), thymus adult (RPKM 114.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Vamp1 in Genome Data Viewer
    Location:
    6 F3; 6 59.32 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125192544..125199269)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125215581..125222306)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17335 Neighboring gene microRNA 3098 Neighboring gene predicted gene, 52878 Neighboring gene STARR-positive B cell enhancer ABC_E1712 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:125172222-125172506 Neighboring gene TAP binding protein-like Neighboring gene RIKEN cDNA E130112N10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6490 Neighboring gene CD27 antigen Neighboring gene microRNA 8113

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in specific granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in tertiary granule membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    vesicle-associated membrane protein 1
    Names
    synaptobrevin-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080557.1NP_001074026.1  vesicle-associated membrane protein 1 isoform b

      See identical proteins and their annotated locations for NP_001074026.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon compared to variant 1. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK018783, BC057587, BU700508, BY640283
      Consensus CDS
      CCDS39637.1
      UniProtKB/TrEMBL
      A0A0N4SUV3
      Related
      ENSMUSP00000098503.3, ENSMUST00000100942.9
      Conserved Domains (2) summary
      cd15870
      Location:3294
      R-SNARE_VAMP2; SNARE motif of VAMP2
      pfam00957
      Location:30102
      Synaptobrevin; Synaptobrevin
    2. NM_009496.3NP_033522.1  vesicle-associated membrane protein 1 isoform a

      See identical proteins and their annotated locations for NP_033522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a)
      Source sequence(s)
      AK018783, BU700508, BY640283
      Consensus CDS
      CCDS20546.1
      UniProtKB/Swiss-Prot
      Q62442, Q6PFF3, Q810K6
      UniProtKB/TrEMBL
      A0A0N4SUV3
      Related
      ENSMUSP00000032487.8, ENSMUST00000032487.14
      Conserved Domains (1) summary
      cd15870
      Location:3294
      R-SNARE_VAMP2; SNARE motif of VAMP2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      125192544..125199269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)