Nat8f5 N-acetyltransferase 8 (GCN5-related) family member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nat8f5provided by MGI
Official Full Name: N-acetyltransferase 8 (GCN5-related) family member 5provided by MGI
Primary source: MGI:MGI:1916299
See related: Ensembl:ENSMUSG00000079494 AllianceGenome:MGI:1916299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cml5; 1810018F03Rik
Summary: Predicted to enable cysteine-S-conjugate N-acetyltransferase activity and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Acts upstream of or within determination of left/right symmetry and heart development. Predicted to be located in Golgi apparatus; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in brain; genitourinary system; gut; and spinal cord. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)) and NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 15.2), small intestine adult (RPKM 12.1) and 7 other tissues See more
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Genomic context

Location:: 6 C3; 6 37.48 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (85794200..85797954, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (85817218..85820972, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyltransferase activity	NAS Non-traceable Author Statement more info	PubMed
enables cysteine-S-conjugate N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation with mouth forming second	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell adhesion	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISA Inferred from Sequence Alignment more info	PubMed
located_in endoplasmic reticulum	ISA Inferred from Sequence Alignment more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	ISO Inferred from Sequence Orthology more info
NOT located_in extracellular space	ISA Inferred from Sequence Alignment more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: probable N-acetyltransferase family 8 member 5

Names: camello-like 5; camello-like protein 5; probable N-acetyltransferase CML5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023493.2 → NP_075982.2 probable N-acetyltransferase family 8 member 5

See identical proteins and their annotated locations for NP_075982.2

Status: VALIDATED

Source sequence(s)

AC162313, AK007530

Consensus CDS

CCDS20300.1

UniProtKB/Swiss-Prot

Q8R1G0, Q9D8Z0, Q9QXS8

Related

ENSMUSP00000032074.4, ENSMUST00000032074.5

Conserved Domains (2) summary

COG0456
Location:125 → 196

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

pfam00583
Location:136 → 193

Acetyltransf_1; Acetyltransferase (GNAT) family