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    Arhgdib Rho, GDP dissociation inhibitor beta [ Mus musculus (house mouse) ]

    Gene ID: 11857, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arhgdibprovided by MGI
    Official Full Name
    Rho, GDP dissociation inhibitor betaprovided by MGI
    Primary source
    MGI:MGI:101940
    See related
    Ensembl:ENSMUSG00000030220 AllianceGenome:MGI:101940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4; Gdid4; Ly-GDI
    Summary
    The protein encoded by this gene is a member of the Rho guanine nucleotide dissociation inhibitor (GDI) family. This gene is expressed at high levels in hematopoietic cells. This protein is cytosolic, and dissociation of Rho from this protein is required for membrane association and activation of Rho by Guanine Nucleotide Exchange Factors (GEFs). C-terminal truncations of this gene product have been reported to promote metastasis. Multiple transcript variants and protein isoforms exist. [provided by RefSeq, Aug 2014]
    Expression
    Biased expression in thymus adult (RPKM 157.4), spleen adult (RPKM 123.8) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arhgdib in Genome Data Viewer
    Location:
    6 G1; 6 66.72 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136900653..136918895, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136923655..136941899, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene matrix Gla protein Neighboring gene endoplasmic reticulum protein 27 Neighboring gene STARR-seq mESC enhancer starr_17614 Neighboring gene STARR-positive B cell enhancer ABC_E3690 Neighboring gene phosphodiesterase 6H, cGMP-specific, cone, gamma Neighboring gene STARR-positive B cell enhancer ABC_E9680 Neighboring gene STARR-positive B cell enhancer mm9_chr6:136929021-136929322 Neighboring gene predicted gene, 30055

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Rho GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Rho GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Rho GDP-dissociation inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of trophoblast cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    rho GDP-dissociation inhibitor 2
    Names
    Rho, GDP dissociation inhibitor (GDI) beta
    rho GDI 2
    rho-GDI beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301301.2NP_001288230.1  rho GDP-dissociation inhibitor 2 isoform 1

      See identical proteins and their annotated locations for NP_001288230.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
      Source sequence(s)
      AC125341
      Consensus CDS
      CCDS20661.1
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
      Related
      ENSMUSP00000107522.2, ENSMUST00000111891.4
      Conserved Domains (1) summary
      pfam02115
      Location:7197
      Rho_GDI; RHO protein GDP dissociation inhibitor
    2. NM_001301303.2NP_001288232.1  rho GDP-dissociation inhibitor 2 isoform 1

      See identical proteins and their annotated locations for NP_001288232.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
      Source sequence(s)
      AC125341
      Consensus CDS
      CCDS20661.1
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
      Conserved Domains (1) summary
      pfam02115
      Location:7197
      Rho_GDI; RHO protein GDP dissociation inhibitor
    3. NM_001301305.2NP_001288234.1  rho GDP-dissociation inhibitor 2 isoform 1

      See identical proteins and their annotated locations for NP_001288234.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
      Source sequence(s)
      AC125341
      Consensus CDS
      CCDS20661.1
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
      Related
      ENSMUSP00000107523.2, ENSMUST00000111892.8
      Conserved Domains (1) summary
      pfam02115
      Location:7197
      Rho_GDI; RHO protein GDP dissociation inhibitor
    4. NM_001301308.2NP_001288237.1  rho GDP-dissociation inhibitor 2 isoform 2

      See identical proteins and their annotated locations for NP_001288237.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon in the coding region and uses a downstream start codon compared to variant 1. Variants 5, 6, and 17-20 all encode isoform 2, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q61599
      Conserved Domains (1) summary
      pfam02115
      Location:1114
      Rho_GDI; RHO protein GDP dissociation inhibitor
    5. NM_001301309.2NP_001288238.1  rho GDP-dissociation inhibitor 2 isoform 2

      See identical proteins and their annotated locations for NP_001288238.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an in-frame exon in the coding region and uses a downstream start codon compared to variant 1. Variants 5, 6, and 17-20 all encode isoform 2, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q61599
      Conserved Domains (1) summary
      pfam02115
      Location:1114
      Rho_GDI; RHO protein GDP dissociation inhibitor
    6. NM_001409490.1NP_001396419.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
    7. NM_001409491.1NP_001396420.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
    8. NM_001409492.1NP_001396421.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
    9. NM_001409493.1NP_001396422.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
    10. NM_001409494.1NP_001396423.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
    11. NM_001409495.1NP_001396424.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
    12. NM_001409497.1NP_001396426.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
    13. NM_001409498.1NP_001396427.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
    14. NM_001409499.1NP_001396428.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
    15. NM_001409500.1NP_001396429.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
    16. NM_001409501.1NP_001396430.1  rho GDP-dissociation inhibitor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125341
    17. NM_001409502.1NP_001396431.1  rho GDP-dissociation inhibitor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125341
    18. NM_001409503.1NP_001396432.1  rho GDP-dissociation inhibitor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125341
    19. NM_001409504.1NP_001396433.1  rho GDP-dissociation inhibitor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125341
    20. NM_007486.6NP_031512.1  rho GDP-dissociation inhibitor 2 isoform 1

      See identical proteins and their annotated locations for NP_031512.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-4 and 7-16 all encode the same isoform (1).
      Source sequence(s)
      AC125341
      Consensus CDS
      CCDS20661.1
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
      Related
      ENSMUSP00000032344.6, ENSMUST00000032344.12
      Conserved Domains (1) summary
      pfam02115
      Location:7197
      Rho_GDI; RHO protein GDP dissociation inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      136900653..136918895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255118.2XP_030110978.1  rho GDP-dissociation inhibitor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
      Conserved Domains (1) summary
      pfam02115
      Location:7197
      Rho_GDI; RHO protein GDP dissociation inhibitor