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    Klhl29 kelch-like 29 [ Mus musculus (house mouse) ]

    Gene ID: 208439, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klhl29provided by MGI
    Official Full Name
    kelch-like 29provided by MGI
    Primary source
    MGI:MGI:2683857
    See related
    Ensembl:ENSMUSG00000020627 AllianceGenome:MGI:2683857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm68; Kbtbd9; mKIAA1921; A230106N14Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human KLHL29 (kelch like family member 29). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 11.1), CNS E18 (RPKM 8.4) and 21 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Klhl29 in Genome Data Viewer
    Location:
    12 A1.1; 12 2.28 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (5127465..5425682, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (5077465..5375682, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ATPase family, AAA domain containing 2B Neighboring gene STARR-seq mESC enhancer starr_31466 Neighboring gene predicted gene, 23167 Neighboring gene RAB11B, member RAS oncogene family pseudogene Neighboring gene STARR-seq mESC enhancer starr_31469 Neighboring gene STARR-seq mESC enhancer starr_31470 Neighboring gene VISTA enhancer mm1338 Neighboring gene predicted gene, 51980 Neighboring gene STARR-seq mESC enhancer starr_31471 Neighboring gene RIKEN cDNA 2810032G03 gene Neighboring gene STARR-seq mESC enhancer starr_31472 Neighboring gene predicted gene, 32214

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    kelch-like protein 29
    Names
    kelch repeat and BTB (POZ) domain containing 9
    kelch repeat and BTB domain-containing protein 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164493.1NP_001157965.1  kelch-like protein 29

      See identical proteins and their annotated locations for NP_001157965.1

      Status: VALIDATED

      Source sequence(s)
      AC131767, BC065168
      Consensus CDS
      CCDS49021.1
      UniProtKB/Swiss-Prot
      A6H646, Q80T74
      UniProtKB/TrEMBL
      A0A1W2P6N5
      Related
      ENSMUSP00000020958.9, ENSMUST00000020958.9
      Conserved Domains (7) summary
      smart00612
      Location:822870
      Kelch; Kelch domain
      PHA03098
      Location:333860
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:673716
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:319427
      BTB; BTB/POZ domain
      pfam01344
      Location:672717
      Kelch_1; Kelch motif
      pfam07707
      Location:436537
      BACK; BTB And C-terminal Kelch
      pfam11235
      Location:40210
      Med25_SD1; Mediator complex subunit 25 synapsin 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      5127465..5425682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)