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    Dnah6 dynein, axonemal, heavy chain 6 [ Mus musculus (house mouse) ]

    Gene ID: 330355, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dnah6provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 6provided by MGI
    Primary source
    MGI:MGI:107744
    See related
    Ensembl:ENSMUSG00000052861 AllianceGenome:MGI:107744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mdhc6; Dnahc6; mKIAA1697; 9830168K20; A730004I20Rik
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to act upstream of or within cilium movement. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; metencephalon part of 4th ventricle choroid plexus; and node. Orthologous to human DNAH6 (dynein axonemal heavy chain 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 4.0), lung adult (RPKM 1.3) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Dnah6 in Genome Data Viewer
    Location:
    6 C1; 6 32.37 cM
    Exon count:
    78
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72994586..73199327, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (73017603..73222227, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16330 Neighboring gene mediator complex subunit 29 pseudogene Neighboring gene predicted gene, 31547 Neighboring gene predicted gene, 20560 Neighboring gene predicted gene, 53334 Neighboring gene predicted gene, 24533 Neighboring gene STARR-seq mESC enhancer starr_16331 Neighboring gene STARR-positive B cell enhancer mm9_chr6:73171622-73171923 Neighboring gene predicted gene, 40377 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:73198236-73198345 Neighboring gene predicted gene, 38834 Neighboring gene succinate-CoA ligase, GDP-forming, alpha subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1697

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule motor activity IC
    Inferred by Curator
    more info
    PubMed 
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium movement IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of inner dynein arm ISM
    Inferred from Sequence Model
    more info
    PubMed 

    General protein information

    Preferred Names
    dynein axonemal heavy chain 6
    Names
    axonemal dynein heavy chain
    dynein, axon, heavy chain 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164669.1NP_001158141.1  dynein axonemal heavy chain 6

      Status: VALIDATED

      Source sequence(s)
      AC122201, AC153842, AC155841
      Consensus CDS
      CCDS51813.1
      UniProtKB/TrEMBL
      E9Q0B6, E9Q3H7
      Related
      ENSMUSP00000068758.7, ENSMUST00000064948.13
      Conserved Domains (5) summary
      pfam03028
      Location:34024132
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:8781296
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:26853017
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:30453261
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:14291659
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72994586..73199327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506302.5XP_006506365.1  dynein axonemal heavy chain 6 isoform X1

      UniProtKB/TrEMBL
      E9Q3H7
      Conserved Domains (3) summary
      COG5245
      Location:11153388
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08393
      Location:8751295
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:14291755
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1

    RNA

    1. XR_003956215.2 RNA Sequence

    2. XR_377473.5 RNA Sequence