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    Adgre1 adhesion G protein-coupled receptor E1 [ Mus musculus (house mouse) ]

    Gene ID: 13733, updated on 3-Dec-2024

    Summary

    Official Symbol
    Adgre1provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor E1provided by MGI
    Primary source
    MGI:MGI:106912
    See related
    Ensembl:ENSMUSG00000004730 AllianceGenome:MGI:106912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emr1; Ly71; F4/80; Gpf480; TM7LN3; DD7A5-7; EGF-TM7
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and liver. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 13.7), mammary gland adult (RPKM 11.5) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adgre1 in Genome Data Viewer
    Location:
    17 D; 17 29.8 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57665650..57790527)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57358581..57483529)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11648 Neighboring gene STARR-positive B cell enhancer ABC_E7549 Neighboring gene STARR-positive B cell enhancer ABC_E9961 Neighboring gene STARR-positive B cell enhancer ABC_E7550 Neighboring gene STARR-positive B cell enhancer ABC_E9962 Neighboring gene STARR-positive B cell enhancer ABC_E8690 Neighboring gene predicted gene, 52326 Neighboring gene vav 1 oncogene Neighboring gene STARR-positive B cell enhancer ABC_E9963 Neighboring gene heat shock protein 8 pseudogene Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene STARR-seq mESC enhancer starr_42922 Neighboring gene vomeronasal 2, receptor 120 Neighboring gene STARR-seq mESC enhancer starr_42923 Neighboring gene STARR-seq mESC enhancer starr_42924 Neighboring gene STARR-seq mESC enhancer starr_42925 Neighboring gene predicted gene, 54014

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (4) 
    • Endonuclease-mediated (7) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor E1
    Names
    EGF-like module containing, mucin-like, hormone receptor-like sequence 1
    EGF-like module receptor 1
    EGF-like module-containing mucin-like hormone receptor-like 1
    EMR1 hormone receptor
    cell surface glycoprotein F4/80

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355722.2NP_001342651.1  adhesion G protein-coupled receptor E1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CT010434
      Consensus CDS
      CCDS50160.1
      UniProtKB/Swiss-Prot
      Q61549
      UniProtKB/TrEMBL
      Q3U1M9, Q3U9R0
      Related
      ENSMUSP00000004850.8, ENSMUST00000004850.8
      Conserved Domains (4) summary
      smart00303
      Location:591640
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:133172
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:222258
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd15439
      Location:644906
      7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    2. NM_001355723.2NP_001342652.1  adhesion G protein-coupled receptor E1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT010434
      UniProtKB/TrEMBL
      Q3U1M9
      Conserved Domains (5) summary
      smart00303
      Location:575624
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:117156
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:206242
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam16489
      Location:420549
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd15439
      Location:628890
      7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    3. NM_001424712.1NP_001411641.1  adhesion G protein-coupled receptor E1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      CT010434
      UniProtKB/TrEMBL
      Q3U1M9
    4. NM_010130.5NP_034260.1  adhesion G protein-coupled receptor E1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034260.1

      Status: VALIDATED

      Source sequence(s)
      CT010434
      Consensus CDS
      CCDS50160.1
      UniProtKB/Swiss-Prot
      Q61549
      UniProtKB/TrEMBL
      Q3U1M9, Q3U9R0
      Related
      ENSMUSP00000083971.6, ENSMUST00000086763.13
      Conserved Domains (4) summary
      smart00303
      Location:591640
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:133172
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:222258
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd15439
      Location:644906
      7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57665650..57790527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160297.1XP_036016190.1  adhesion G protein-coupled receptor E1 isoform X1

      UniProtKB/TrEMBL
      Q3U1M9
      Conserved Domains (4) summary
      smart00303
      Location:552601
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:133172
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:222258
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd15439
      Location:605867
      7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors