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    Helz helicase with zinc finger domain [ Mus musculus (house mouse) ]

    Gene ID: 78455, updated on 9-Dec-2024

    Summary

    Official Symbol
    Helzprovided by MGI
    Official Full Name
    helicase with zinc finger domainprovided by MGI
    Primary source
    MGI:MGI:1925705
    See related
    Ensembl:ENSMUSG00000020721 AllianceGenome:MGI:1925705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DRHC; 3110078M01Rik; 9430093I07Rik; 9630002H22Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in nucleus. Predicted to be active in P granule and cytosol. Is expressed in retina outer nuclear layer. Orthologous to human HELZ (helicase with zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.0), placenta adult (RPKM 5.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Helz in Genome Data Viewer
    Location:
    11 E1; 11 70.29 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (107437789..107584652)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (107546963..107693826)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:107340564-107340865 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 Neighboring gene STARR-seq mESC enhancer starr_30988 Neighboring gene RIKEN cDNA A830035A12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107390700-107390809 Neighboring gene STARR-seq mESC enhancer starr_30991 Neighboring gene predicted gene, 39426 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107434682-107434883 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107436638-107436803 Neighboring gene STARR-seq mESC enhancer starr_30994 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107505802-107506005 Neighboring gene microRNA 6932 Neighboring gene calcium channel, voltage-dependent, gamma subunit 1 Neighboring gene calcium channel, voltage-dependent, gamma subunit 4 Neighboring gene VISTA enhancer mm1348 Neighboring gene predicted gene 11650

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0054

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    probable helicase with zinc finger domain
    NP_001355684.1
    NP_938040.1
    XP_006534567.1
    XP_006534568.1
    XP_006534569.1
    XP_030102290.1
    XP_036012985.1
    XP_036012986.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368755.1NP_001355684.1  probable helicase with zinc finger domain isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645947
      Consensus CDS
      CCDS88275.1
      UniProtKB/Swiss-Prot
      A1L4L4, A2AAU4, Q6DFV5, Q8BZZ6, Q8CHI3, Q8VDI3
      Related
      ENSMUSP00000102357.2, ENSMUST00000106746.8
      Conserved Domains (5) summary
      smart00818
      Location:13371413
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:8681068
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641867
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:12611415
      Atrophin-1; Atrophin-1 family
    2. NM_198298.2NP_938040.1  probable helicase with zinc finger domain isoform 1

      See identical proteins and their annotated locations for NP_938040.1

      Status: VALIDATED

      Source sequence(s)
      AL645947
      Consensus CDS
      CCDS25569.1
      UniProtKB/Swiss-Prot
      Q6DFV5
      UniProtKB/TrEMBL
      A0A0R4J0Y3
      Related
      ENSMUSP00000074533.2, ENSMUST00000075012.8
      Conserved Domains (5) summary
      smart00818
      Location:13381414
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:8691069
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641868
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:12621416
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      107437789..107584652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534505.5XP_006534568.1  probable helicase with zinc finger domain isoform X1

      See identical proteins and their annotated locations for XP_006534568.1

      UniProtKB/Swiss-Prot
      Q6DFV5
      UniProtKB/TrEMBL
      A0A0R4J0Y3
      Conserved Domains (5) summary
      smart00818
      Location:13381414
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:8691069
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641868
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:12621416
      Atrophin-1; Atrophin-1 family
    2. XM_006534506.5XP_006534569.1  probable helicase with zinc finger domain isoform X1

      See identical proteins and their annotated locations for XP_006534569.1

      UniProtKB/Swiss-Prot
      Q6DFV5
      UniProtKB/TrEMBL
      A0A0R4J0Y3
      Conserved Domains (5) summary
      smart00818
      Location:13381414
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:8691069
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641868
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:12621416
      Atrophin-1; Atrophin-1 family
    3. XM_006534504.1XP_006534567.1  probable helicase with zinc finger domain isoform X1

      See identical proteins and their annotated locations for XP_006534567.1

      UniProtKB/Swiss-Prot
      Q6DFV5
      UniProtKB/TrEMBL
      A0A0R4J0Y3
      Conserved Domains (5) summary
      smart00818
      Location:13381414
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:8691069
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641868
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:12621416
      Atrophin-1; Atrophin-1 family
    4. XM_036157092.1XP_036012985.1  probable helicase with zinc finger domain isoform X3

      Conserved Domains (4) summary
      cd18808
      Location:8341034
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      pfam00642
      Location:181205
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:11431374
      Atrophin-1; Atrophin-1 family
      cl28899
      Location:641833
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    5. XM_030246430.1XP_030102290.1  probable helicase with zinc finger domain isoform X2

      UniProtKB/Swiss-Prot
      A1L4L4, A2AAU4, Q6DFV5, Q8BZZ6, Q8CHI3, Q8VDI3
      Related
      ENSMUSP00000097878.2, ENSMUST00000100305.8
      Conserved Domains (5) summary
      smart00818
      Location:13371413
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd18808
      Location:8681068
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18077
      Location:641867
      DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
      pfam00642
      Location:181204
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:12611415
      Atrophin-1; Atrophin-1 family
    6. XM_036157093.1XP_036012986.1  probable helicase with zinc finger domain isoform X3

      Conserved Domains (4) summary
      cd18808
      Location:8341034
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      pfam00642
      Location:181205
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam03154
      Location:11431374
      Atrophin-1; Atrophin-1 family
      cl28899
      Location:641833
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily