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    Mtcl2 microtubule crosslinking factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 320706, updated on 27-Nov-2024

    Summary

    Official Symbol
    Mtcl2provided by MGI
    Official Full Name
    microtubule crosslinking factor 2provided by MGI
    Primary source
    MGI:MGI:2444575
    See related
    Ensembl:ENSMUSG00000055485 AllianceGenome:MGI:2444575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Soga; Soga1; 9830001H06Rik; D430036N24Rik
    Summary
    Involved in insulin receptor signaling pathway; negative regulation of gluconeogenesis; and regulation of autophagy. Located in extracellular space and microtubule. Orthologous to human MTCL2 (microtubule crosslinking factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 16.8), lung adult (RPKM 13.8) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mtcl2 in Genome Data Viewer
    Location:
    2 H1; 2 77.91 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156852361..156921185, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157010441..157079667, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene DSN1 homolog, MIS12 kinetochore complex component Neighboring gene STARR-seq mESC enhancer starr_06195 Neighboring gene STARR-seq mESC enhancer starr_06196 Neighboring gene TBC/LysM associated domain containing 2 Neighboring gene SAM domain and HD domain, 1 Neighboring gene STARR-seq mESC enhancer starr_06197 Neighboring gene STARR-positive B cell enhancer ABC_E6008 Neighboring gene STARR-positive B cell enhancer ABC_E7876 Neighboring gene STARR-positive B cell enhancer ABC_E2649 Neighboring gene STARR-seq mESC enhancer starr_06198 Neighboring gene RB transcriptional corepressor like 1 Neighboring gene Small nuclear ribonucleoprotein Sm D1 (snRNP core protein D1) (Sm-D1) (Sm-D autoantigen)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    microtubule cross-linking factor 2
    Names
    SOGA family member 1
    protein SOGA1
    suppressor of glucose by autophagy
    suppressor of glucose, autophagy associated 1
    suppressor of glucose, autophagy-associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164663.1NP_001158135.1  microtubule cross-linking factor 2

      Status: VALIDATED

      Source sequence(s)
      AK147227, AL669932, CJ164427
      Consensus CDS
      CCDS50781.1
      UniProtKB/Swiss-Prot
      A2ACV6, E1U8D0
      Related
      ENSMUSP00000066556.7, ENSMUST00000069098.7
      Conserved Domains (3) summary
      pfam00261
      Location:294555
      Tropomyosin; Tropomyosin
      pfam11365
      Location:378472
      DUF3166; Protein of unknown function (DUF3166)
      pfam14818
      Location:10651202
      DUF4482; Domain of unknown function (DUF4482)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      156852361..156921185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319023.3XP_017174512.3  microtubule cross-linking factor 2 isoform X2

      Conserved Domains (5) summary
      PHA03307
      Location:28211
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:214548
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:2511090
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11365
      Location:504593
      SOGA; Protein SOGA
      pfam14818
      Location:10181156
      DUF4482; Domain of unknown function (DUF4482)
    2. XM_036162310.1XP_036018203.1  microtubule cross-linking factor 2 isoform X1

      Conserved Domains (5) summary
      PHA03307
      Location:28211
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:214548
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:2511108
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11365
      Location:504593
      SOGA; Protein SOGA
      pfam14818
      Location:10651201
      DUF4482; Domain of unknown function (DUF4482)