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    PsGEF Protostome-specific GEF [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31224, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PsGEFprovided by FlyBase
    Official Full Name
    Protostome-specific GEFprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264598
    Locus tag
    Dmel_CG43947
    See related
    AllianceGenome:FB:FBgn0264598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14045; CG14047; CG43947; Dmel\CG43947; DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2; FBgn0264598; null; psGEF; PsGef
    Old locus tag
    Dmel_CG14045; Dmel_CG14047
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including mushroom body development; positive regulation of Rac protein signal transduction; and positive regulation of ruffle assembly. Located in cytoplasm. Is expressed in several structures, including adult antennal lobe; adult head; adult mushroom body; adult optic lobe; and ganglia. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PsGEF in Genome Data Viewer
    Location:
    3A2-3A2; 1-1 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2367121..2387664, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2261154..2281697, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC). Baranov PV, et al. RNA Biol, 2011 Jul-Aug. PMID 21593603, Free PMC Article
    2. Reliance of Wolbachia on High Rates of Host Proteolysis Revealed by a Genome-Wide RNAi Screen of Drosophila Cells. White PM, et al. Genetics, 2017 Apr. PMID 28159754, Free PMC Article
    3. Specific retention of the protostome-specific PsGEF may parallel with the evolution of mushroom bodies in insect and lophotrochozoan brains. Higuchi N, et al. BMC Biol, 2009 May 7. PMID 19422675, Free PMC Article
    4. A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment. Jones MA, et al. Exp Gerontol, 2009 Aug. PMID 19481596, Free PMC Article
    5. Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth. Campbell K, et al. PLoS Genet, 2018 Feb. PMID 29420531, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mushroom body development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of Rac protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ruffle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protostome-specific GEF
    Names
    CG43947-PA
    CG43947-PB
    CG43947-PC
    CG43947-PE
    CG43947-PF
    CG43947-PG
    CG43947-PH
    CG43947-PI
    PsGEF-PA
    PsGEF-PB
    PsGEF-PC
    PsGEF-PE
    PsGEF-PF
    PsGEF-PG
    PsGEF-PH
    PsGEF-PI
    protostome-specific GEF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2367121..2387664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130645.6 → NP_570001.5  Protostome-specific GEF, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570001.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4Z0
      Conserved Domains (4) summary
      cd00992
      Location:608 → 680
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00168
      Location:286 → 413
      C2; C2 domain
      pfam16056
      Location:102 → 209
      DUF4799; Domain of unknown function (DUF4799)
      cl02571
      Location:795 → 964
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    2. NM_001272259.1 → NP_001259188.1  Protostome-specific GEF, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGV0
      Conserved Domains (4) summary
      cd00992
      Location:608 → 680
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00168
      Location:286 → 413
      C2; C2 domain
      pfam16056
      Location:102 → 209
      DUF4799; Domain of unknown function (DUF4799)
      cl02571
      Location:795 → 964
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    3. NM_001272258.1 → NP_001259187.1  Protostome-specific GEF, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259187.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGC1
      Conserved Domains (4) summary
      cd00992
      Location:608 → 680
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00168
      Location:286 → 413
      C2; C2 domain
      pfam16056
      Location:102 → 209
      DUF4799; Domain of unknown function (DUF4799)
      cl02571
      Location:795 → 964
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    4. NM_206610.5 → NP_996333.4  Protostome-specific GEF, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996333.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVY9
      Conserved Domains (4) summary
      cd00992
      Location:644 → 716
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00168
      Location:286 → 381
      C2; C2 domain
      pfam16056
      Location:102 → 209
      DUF4799; Domain of unknown function (DUF4799)
      cl02571
      Location:831 → 1000
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    5. NM_001272260.1 → NP_001259189.1  Protostome-specific GEF, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259189.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGJ2
      Conserved Domains (4) summary
      cd00992
      Location:608 → 680
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00168
      Location:286 → 413
      C2; C2 domain
      pfam16056
      Location:66 → 209
      DUF4799; Domain of unknown function (DUF4799)
      cl02571
      Location:795 → 964
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    6. NM_001169176.2 → NP_001162647.1  Protostome-specific GEF, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162647.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJB8
      Conserved Domains (4) summary
      cd00992
      Location:608 → 680
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00168
      Location:286 → 413
      C2; C2 domain
      pfam16056
      Location:66 → 209
      DUF4799; Domain of unknown function (DUF4799)
      cl02571
      Location:795 → 964
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    7. NM_130646.3 → NP_570002.1  Protostome-specific GEF, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570002.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1M5, Q9W4Y9
      Conserved Domains (4) summary
      cd00992
      Location:644 → 716
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00168
      Location:286 → 381
      C2; C2 domain
      pfam16056
      Location:66 → 209
      DUF4799; Domain of unknown function (DUF4799)
      cl02571
      Location:831 → 1000
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    8. NM_001169175.2 → NP_001162646.1  Protostome-specific GEF, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162646.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R48, Q9U1M4
      Conserved Domains (3) summary
      cd00992
      Location:608 → 680
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00168
      Location:286 → 413
      C2; C2 domain
      pfam16056
      Location:96 → 209
      DUF4799; Domain of unknown function (DUF4799)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJB8 E1JJB8
    M9PGC1 M9PGC1
    M9PGJ2 M9PGJ2
    M9PGV0 M9PGV0
    Q29R48 Q29R48
    Q7K6U7 Q7K6U7
    Q7KVY9 Q7KVY9
    Q9U1M4 Q9U1M4
    Q9W4Y9 Q9W4Y9
    Q9W4Z0 Q9W4Z0

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