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    Scd2 stearoyl-Coenzyme A desaturase 2 [ Mus musculus (house mouse) ]

    Gene ID: 20250, updated on 27-Nov-2024

    Summary

    Official Symbol
    Scd2provided by MGI
    Official Full Name
    stearoyl-Coenzyme A desaturase 2provided by MGI
    Primary source
    MGI:MGI:98240
    See related
    Ensembl:ENSMUSG00000025203 AllianceGenome:MGI:98240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    swty; Scd-2; Mir5114; mir-5114
    Summary
    Enables palmitoyl-CoA 9-desaturase activity and stearoyl-CoA 9-desaturase activity. Acts upstream of or within monounsaturated fatty acid biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 186.3), subcutaneous fat pad adult (RPKM 170.4) and 25 other tissues See more
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    Genomic context

    See Scd2 in Genome Data Viewer
    Location:
    19 C3; 19 37.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44282115..44295303)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44293676..44306864)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46225 Neighboring gene predicted gene, 54046 Neighboring gene predicted gene, 35183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:44358612-44358721 Neighboring gene STARR-positive B cell enhancer ABC_E4283 Neighboring gene predicted gene, 41853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:44368225-44368334 Neighboring gene STARR-positive B cell enhancer ABC_E2528 Neighboring gene microRNA 5114 Neighboring gene STARR-seq mESC enhancer starr_46229 Neighboring gene STARR-seq mESC enhancer starr_46230 Neighboring gene stearoyl-coenzyme A desaturase 4 Neighboring gene STARR-positive B cell enhancer ABC_E4284 Neighboring gene STARR-positive B cell enhancer ABC_E972 Neighboring gene STARR-positive B cell enhancer ABC_E7663 Neighboring gene STARR-seq mESC enhancer starr_46234 Neighboring gene stearoyl-Coenzyme A desaturase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables palmitoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables palmitoyl-CoA 9-desaturase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables palmitoyl-CoA 9-desaturase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables stearoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables stearoyl-CoA 9-desaturase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables stearoyl-CoA 9-desaturase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables stearoyl-CoA 9-desaturase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in monounsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in unsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in unsaturated fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    stearoyl-CoA desaturase 2
    Names
    Acyl-CoA desaturase 2 (Stearoyl-CoA desaturase 2) (Fatty acid desaturase 2) (Delta(9)-desaturase 2)
    delta(9)-desaturase 2
    fatty acid desaturase 2
    NP_033154.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009128.2NP_033154.2  stearoyl-CoA desaturase 2

      See identical proteins and their annotated locations for NP_033154.2

      Status: VALIDATED

      Source sequence(s)
      AK083922, AK159413, CF168778, CJ110442, CJ242760
      Consensus CDS
      CCDS29848.1
      UniProtKB/Swiss-Prot
      P13011, Q8BH96
      Related
      ENSMUSP00000026221.6, ENSMUST00000026221.7
      Conserved Domains (1) summary
      cd03505
      Location:96336
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44282115..44295303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)