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    Timd2 T cell immunoglobulin and mucin domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 171284, updated on 9-Dec-2024

    Summary

    Official Symbol
    Timd2provided by MGI
    Official Full Name
    T cell immunoglobulin and mucin domain containing 2provided by MGI
    Primary source
    MGI:MGI:2159681
    See related
    Ensembl:ENSMUSG00000040413 AllianceGenome:MGI:2159681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G9D3; Tim2; TIM-2
    Summary
    Enables ferritin receptor activity. Acts upstream of or within iron ion transport. Located in cell surface. Is expressed in 4-cell stage embryo; liver; liver left lobe; liver right lobe; and metanephros. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 18.2), liver adult (RPKM 17.7) and 4 other tissues See more
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    Genomic context

    See Timd2 in Genome Data Viewer
    Location:
    11 B1.1; 11 28.05 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (46559787..46597934, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46668960..46707107, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 1 Neighboring gene T cell immunoglobulin and mucin domain containing 7, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3944 Neighboring gene STARR-seq mESC enhancer starr_29333 Neighboring gene predicted gene 12174 Neighboring gene hepatitis A virus cellular receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ferritin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables virus receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within iron ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mast cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    T-cell immunoglobulin and mucin domain-containing protein 2
    Names
    T-cell immunoglobulin mucin receptor 2
    T-cell membrane protein 2
    TIMD-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161355.1NP_001154827.1  T-cell immunoglobulin and mucin domain-containing protein 2 precursor

      See identical proteins and their annotated locations for NP_001154827.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), variant 2 and variant 3 encode the same protein.
      Source sequence(s)
      AK145630, AK163225, AK166877, CB953226
      Consensus CDS
      CCDS24582.1
      UniProtKB/Swiss-Prot
      Q8R183, Q8VBW0
      UniProtKB/TrEMBL
      A8C1R4
      Related
      ENSMUSP00000104848.3, ENSMUST00000109225.9
      Conserved Domains (1) summary
      pfam07686
      Location:30119
      V-set; Immunoglobulin V-set domain
    2. NM_001161356.1NP_001154828.1  T-cell immunoglobulin and mucin domain-containing protein 2 precursor

      See identical proteins and their annotated locations for NP_001154828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR, as compared to variant 1.
      Source sequence(s)
      AB009015, AK145630, AK166877
      Consensus CDS
      CCDS24582.1
      UniProtKB/Swiss-Prot
      Q8R183, Q8VBW0
      UniProtKB/TrEMBL
      A8C1R4
      Related
      ENSMUSP00000131540.2, ENSMUST00000169584.8
      Conserved Domains (1) summary
      pfam07686
      Location:30119
      V-set; Immunoglobulin V-set domain
    3. NM_134249.5NP_599010.4  T-cell immunoglobulin and mucin domain-containing protein 2 precursor

      See identical proteins and their annotated locations for NP_599010.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1.
      Source sequence(s)
      AK145630, AK163225, AK166877, BY731803
      Consensus CDS
      CCDS24582.1
      UniProtKB/Swiss-Prot
      Q8R183, Q8VBW0
      UniProtKB/TrEMBL
      A8C1R4
      Related
      ENSMUSP00000060891.7, ENSMUST00000055102.13
      Conserved Domains (1) summary
      pfam07686
      Location:30119
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      46559787..46597934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245625.1XP_030101485.1  T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8R183, Q8VBW0
      UniProtKB/TrEMBL
      A8C1R4
      Conserved Domains (1) summary
      pfam07686
      Location:30119
      V-set; Immunoglobulin V-set domain
    2. XM_030245624.1XP_030101484.1  T-cell immunoglobulin and mucin domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8R183, Q8VBW0
      UniProtKB/TrEMBL
      A8C1R4
      Conserved Domains (1) summary
      pfam07686
      Location:30119
      V-set; Immunoglobulin V-set domain