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    Wnt8b wingless-type MMTV integration site family, member 8B [ Mus musculus (house mouse) ]

    Gene ID: 22423, updated on 3-Dec-2024

    Summary

    Official Symbol
    Wnt8bprovided by MGI
    Official Full Name
    wingless-type MMTV integration site family, member 8Bprovided by MGI
    Primary source
    MGI:MGI:109485
    See related
    Ensembl:ENSMUSG00000036961 AllianceGenome:MGI:109485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within negative regulation of gene expression and positive regulation of gene expression. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cochlea; eye; future brain; head mesenchyme; and nervous system. Human ortholog(s) of this gene implicated in Hirschsprung's disease. Orthologous to human WNT8B (Wnt family member 8B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 4.9), thymus adult (RPKM 1.6) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Wnt8b in Genome Data Viewer
    Location:
    19 C3; 19 37.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44481912..44502712)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44493472..44514273)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene stearoyl-Coenzyme A desaturase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:44531852-44532152 Neighboring gene predicted gene, 35406 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:44587253-44587525 Neighboring gene SEC31 homolog B, COPII coat complex component Neighboring gene NADH:ubiquinone oxidoreductase subunit B8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein Wnt-8b
    Names
    wingless related MMTV integration site 8b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011720.4NP_035850.3  protein Wnt-8b precursor

      Status: VALIDATED

      Source sequence(s)
      AC151478
      Consensus CDS
      CCDS50446.1
      UniProtKB/Swiss-Prot
      Q9WUD6
      UniProtKB/TrEMBL
      Q0VDS2
      Related
      ENSMUSP00000042867.5, ENSMUST00000041163.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44481912..44502712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)