U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Adam23 a disintegrin and metallopeptidase domain 23 [ Mus musculus (house mouse) ]

    Gene ID: 23792, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adam23provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 23provided by MGI
    Primary source
    MGI:MGI:1345162
    See related
    Ensembl:ENSMUSG00000025964 AllianceGenome:MGI:1345162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MDC3
    Summary
    This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an inactive metalloprotease and disintegrin domains. Transgenic disruption of this gene in mice results in postnatal neurological defects including tremor and ataxia resulting in death by 2 weeks of age. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in cerebellum adult (RPKM 24.9), cortex adult (RPKM 15.1) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    1 C2; 1 32.31 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63484880..63635263)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63445717..63596111)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01139 Neighboring gene STARR-seq mESC enhancer starr_01140 Neighboring gene predicted gene, 35393 Neighboring gene STARR-seq mESC enhancer starr_01141 Neighboring gene predicted gene, 22281 Neighboring gene STARR-seq mESC enhancer starr_01142 Neighboring gene family with sequence similarity 237, member A Neighboring gene dystrotelin Neighboring gene STARR-seq mESC enhancer starr_01143

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 23
    Names
    a disintegrin and metalloprotease domain 23
    metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011780.3NP_035910.1  disintegrin and metalloproteinase domain-containing protein 23 preproprotein

      See identical proteins and their annotated locations for NP_035910.1

      Status: REVIEWED

      Source sequence(s)
      AB009673, AK046677, AL645534, AW046396
      Consensus CDS
      CCDS14999.1
      UniProtKB/Swiss-Prot
      Q6QDY9, Q6QDZ0, Q8CC33, Q9R1V7
      Related
      ENSMUSP00000084633.4, ENSMUST00000087374.10
      Conserved Domains (5) summary
      smart00608
      Location:584723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:296491
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:508581
      Disintegrin; Disintegrin
      pfam01421
      Location:296493
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:144246
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      63484880..63635263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495969.5XP_006496032.1  disintegrin and metalloproteinase domain-containing protein 23 isoform X1

      UniProtKB/Swiss-Prot
      Q9R1V7
      Related
      ENSMUSP00000109742.2, ENSMUST00000114107.3
      Conserved Domains (4) summary
      smart00608
      Location:584723
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:508580
      Disintegrin
      pfam01421
      Location:296493
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:124246
      Pep_M12B_propep; Reprolysin family propeptide
    2. XM_006495970.5XP_006496033.1  disintegrin and metalloproteinase domain-containing protein 23 isoform X2

      UniProtKB/Swiss-Prot
      Q9R1V7
      Related
      ENSMUSP00000139862.2, ENSMUST00000114103.8
      Conserved Domains (4) summary
      smart00608
      Location:584723
      ACR; ADAM Cysteine-Rich Domain
      pfam00200
      Location:508580
      Disintegrin
      pfam01421
      Location:296493
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:124246
      Pep_M12B_propep; Reprolysin family propeptide

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001177600.1: Suppressed sequence

      Description
      NM_001177600.1: This RefSeq was removed because currently there is insufficient support for the transcript.