Eif1b eukaryotic translation initiation factor 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif1bprovided by MGI
Official Full Name: eukaryotic translation initiation factor 1Bprovided by MGI
Primary source: MGI:MGI:1916219
See related: Ensembl:ENSMUSG00000006941 AllianceGenome:MGI:1916219
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gc20; 1500010M16Rik; 3110001N14Rik
Summary: Predicted to enable RNA binding activity; ribosomal small subunit binding activity; and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic 43S preinitiation complex. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human EIF1B (eukaryotic translation initiation factor 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 70.4), CNS E14 (RPKM 53.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 71.67 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (120321672..120324393)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (120492606..120495327)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of TPPP2 might affect the translation of specific proteins, such as eEf1b, altering the structure and function of sperm mitochondria, and resulting in decreased sperm count, motility and fertility.
Title: Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal small subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of eukaryotic 43S preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 1b

Names: translation factor sui1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026892.3 → NP_081168.1 eukaryotic translation initiation factor 1b

Status: VALIDATED

Source sequence(s)

AI154212, AK005192, AK013965

Consensus CDS

CCDS23628.1

UniProtKB/Swiss-Prot

Q9CXU9

UniProtKB/TrEMBL

Q3UBT8

Related

ENSMUSP00000007139.5, ENSMUST00000007139.6

Conserved Domains (1) summary

cl00229
Location:4 → 113

eIF1_SUI1_like; Eukaryotic initiation factor 1 and related proteins