U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mdh1b malate dehydrogenase 1B, NAD (soluble) [ Mus musculus (house mouse) ]

    Gene ID: 76668, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mdh1bprovided by MGI
    Official Full Name
    malate dehydrogenase 1B, NAD (soluble)provided by MGI
    Primary source
    MGI:MGI:1923918
    See related
    Ensembl:ENSMUSG00000025963 AllianceGenome:MGI:1923918
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700124B08Rik
    Summary
    Predicted to enable L-malate dehydrogenase (NAD+) activity. Predicted to be involved in NADH metabolic process; dicarboxylic acid metabolic process; and tricarboxylic acid cycle. Is expressed in cerebral cortex; heart; and liver. Orthologous to human MDH1B (malate dehydrogenase 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 20.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mdh1b in Genome Data Viewer
    Location:
    1 C2; 1 32.31 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63726732..63769707, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63698827..63730318, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01142 Neighboring gene family with sequence similarity 237, member A Neighboring gene dystrotelin Neighboring gene STARR-seq mESC enhancer starr_01143 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:63777041-63777224 Neighboring gene FAST kinase domains 2 Neighboring gene RIKEN cDNA 4933402D24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:63810015-63810202

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables malate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in NADH metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oxaloacetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative malate dehydrogenase 1B
    NP_083972.3
    XP_036010132.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029696.5NP_083972.3  putative malate dehydrogenase 1B

      See identical proteins and their annotated locations for NP_083972.3

      Status: VALIDATED

      Source sequence(s)
      AC099637, AL645534
      Consensus CDS
      CCDS15000.2
      UniProtKB/Swiss-Prot
      Q5F204, Q80YT6, Q9D988
      Related
      ENSMUSP00000109728.3, ENSMUST00000114094.3
      Conserved Domains (2) summary
      TIGR01759
      Location:130457
      MalateDH-SF1; malate dehydrogenase
      cl21454
      Location:9459
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      63726732..63769707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154239.1XP_036010132.1  putative malate dehydrogenase 1B isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:9459
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins