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    Mgl2 macrophage galactose N-acetyl-galactosamine specific lectin 2 [ Mus musculus (house mouse) ]

    Gene ID: 216864, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mgl2provided by MGI
    Official Full Name
    macrophage galactose N-acetyl-galactosamine specific lectin 2provided by MGI
    Primary source
    MGI:MGI:2385729
    See related
    Ensembl:ENSMUSG00000040950 AllianceGenome:MGI:2385729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD301b
    Summary
    Enables carbohydrate binding activity. Predicted to be involved in immune response. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including hemolymphoid system gland; ileum; liver; lung; and male reproductive gland or organ. Orthologous to human CLEC10A (C-type lectin domain containing 10A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 12.3), mammary gland adult (RPKM 12.0) and 14 other tissues See more
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    Genomic context

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    See Mgl2 in Genome Data Viewer
    Location:
    11 B3; 11 42.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70020953..70028368)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70130125..70137542)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32946 Neighboring gene asialoglycoprotein receptor 2 Neighboring gene predicted gene 12311 Neighboring gene STARR-seq mESC enhancer starr_29870 Neighboring gene C-type lectin domain family 10, member A Neighboring gene STARR-seq mESC enhancer starr_29871 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity. Kumamoto Y, et al. Immunity, 2013 Oct 17. PMID 24076051, Free PMC Article
    2. Macrophage Gal/GalNAc lectin 2 (MGL2)(+) peritoneal antigen presenting cells during Fasciola hepatica infection are essential for regulatory T cell induction. Costa M, et al. Sci Rep, 2022 Oct 21. PMID 36271272, Free PMC Article
    3. Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells. Denda-Nagai K, et al. J Biol Chem, 2010 Jun 18. PMID 20304916, Free PMC Article
    4. The Tn antigen promotes lung tumor growth by fostering immunosuppression and angiogenesis via interaction with Macrophage Galactose-type lectin 2 (MGL2). da Costa V, et al. Cancer Lett, 2021 Oct 10. PMID 34144098
    5. MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo. Kumamoto Y, et al. PLoS One, 2009. PMID 19440334, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD301b[+] macrophage: the new booster for activating bone regeneration in periodontitis treatment.
      Title: CD301b(+) macrophage: the new booster for activating bone regeneration in periodontitis treatment.
    2. Effective CD4 T cell priming requires repertoire scanning by CD301b(+) migratory cDC2 cells upon lymph node entry.
      Title: Effective CD4 T cell priming requires repertoire scanning by CD301b(+) migratory cDC2 cells upon lymph node entry.
    3. The Tn antigen promotes lung tumor growth by fostering immunosuppression and angiogenesis via interaction with Macrophage Galactose-type lectin 2 (MGL2).
      Title: The Tn antigen promotes lung tumor growth by fostering immunosuppression and angiogenesis via interaction with Macrophage Galactose-type lectin 2 (MGL2).
    4. CD301b/MGL2(+) Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis.
      Title: CD301b/MGL2(+) Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis.
    5. Reconstituting RELMalpha in CD301b(+) MNP-depleted animals restored body weight.
      Title: CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.
    6. CD301b dermal dendritic cells drive T helper 2 cell-mediated immunity.
      Title: CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity.
    7. analysis of macrophage galactose-type C-type lectin 2 (MGL2/CD301b) uptake and presentation of glycosylated antigens by dendritic cells
      Title: Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells.
    8. The results demonstrated the availability of MGL2 as a novel marker for DDCs and suggested the contribution of MGL2(+) DDCs for initiating CHS.
      Title: MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo.
    9. Mutations of MGL2 CRD at Leu, Arg, Arg, and Tyr at positions 61, 89, 115 and 125 were implicated in the preference for beta-GalNAc.
      Title: The amino acids involved in the distinct carbohydrate specificities between macrophage galactose-type C-type lectins 1 and 2 (CD301a and b) of mice.
    10. The mMGL2 protein is induced in diverse populations of aaMF, including peritoneal macrophages elicited during infection with the protozoan Trypanosoma brucei brucei or the Helminth Taenia crassiceps and alveolar macrophages elicited.
      Title: Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (7)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123660, MGC123939, MGC124077

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fucose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    macrophage galactose N-acetyl-galactosamine specific lectin 2
    Names
    macrophage galactose-type C-type lectin 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145137.2 → NP_660119.1  macrophage galactose N-acetyl-galactosamine specific lectin 2

      See identical proteins and their annotated locations for NP_660119.1

      Status: VALIDATED

      Source sequence(s)
      BC106833, BY198732, BY544307
      Consensus CDS
      CCDS24935.1
      UniProtKB/TrEMBL
      F6QSC4, Q8JZN1
      Related
      ENSMUSP00000048568.6, ENSMUST00000041550.12
      Conserved Domains (2) summary
      cd03590
      Location:189 → 314
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:38 → 179
      Lectin_N; Hepatic lectin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70020953..70028368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532912.2 → XP_006532975.1  macrophage galactose N-acetyl-galactosamine specific lectin 2 isoform X1

      See identical proteins and their annotated locations for XP_006532975.1

      UniProtKB/TrEMBL
      A9XX86, F6QSC4
      Related
      ENSMUSP00000131344.2, ENSMUST00000165951.8
      Conserved Domains (2) summary
      cd03590
      Location:190 → 363
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:39 → 180
      Lectin_N; Hepatic lectin, N-terminal domain

    2. XM_006532913.4 → XP_006532976.1  macrophage galactose N-acetyl-galactosamine specific lectin 2 isoform X2

      See identical proteins and their annotated locations for XP_006532976.1

      UniProtKB/TrEMBL
      F6QSC4
      Related
      ENSMUSP00000104225.2, ENSMUST00000108584.2
      Conserved Domains (2) summary
      cd03590
      Location:189 → 362
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:38 → 179
      Lectin_N; Hepatic lectin, N-terminal domain

    3. XM_006532915.2 → XP_006532978.1  macrophage galactose N-acetyl-galactosamine specific lectin 2 isoform X5

      See identical proteins and their annotated locations for XP_006532978.1

      UniProtKB/TrEMBL
      F6QSC4
      Conserved Domains (2) summary
      cd03590
      Location:190 → 315
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:39 → 180
      Lectin_N; Hepatic lectin, N-terminal domain

    4. XM_017314459.1 → XP_017169948.1  macrophage galactose N-acetyl-galactosamine specific lectin 2 isoform X4

      UniProtKB/TrEMBL
      Q8BUD5
      Conserved Domains (2) summary
      cd03590
      Location:159 → 332
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:2 → 149
      Lectin_N; Hepatic lectin, N-terminal domain

    5. XM_006532914.4 → XP_006532977.1  macrophage galactose N-acetyl-galactosamine specific lectin 2 isoform X3

      See identical proteins and their annotated locations for XP_006532977.1

      UniProtKB/TrEMBL
      Q8BUD5
      Conserved Domains (2) summary
      cd03590
      Location:160 → 333
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam03954
      Location:2 → 150
      Lectin_N; Hepatic lectin, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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