Fam222a family with sequence similarity 222, member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fam222aprovided by MGI
Official Full Name: family with sequence similarity 222, member Aprovided by MGI
Primary source: MGI:MGI:3605543
See related: Ensembl:ENSMUSG00000041930 AllianceGenome:MGI:3605543
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Is expressed in inner ear and lens. Orthologous to human FAM222A (family with sequence similarity 222 member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in adrenal adult (RPKM 28.4), ovary adult (RPKM 21.0) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 55.99 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (114706312..114751281)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (114568251..114613220)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report.
Title: FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report.
Study reports FAM222A as a putative brain atrophy susceptibility gene. The protein encoded by FAM222A is predominantly expressed in the CNS and is increased in brains of patients with Alzheimer's disease (AD) and in an AD mouse model. It accumulates within amyloid deposits, physically interacts with amyloid-beta (Abeta) via its N-terminal Abeta binding domain and facilitates Abeta aggregation.
Title: FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: protein FAM222A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.