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    Nol12 nucleolar protein 12 [ Mus musculus (house mouse) ]

    Gene ID: 97961, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nol12provided by MGI
    Official Full Name
    nucleolar protein 12provided by MGI
    Primary source
    MGI:MGI:2146285
    See related
    Ensembl:ENSMUSG00000033099 AllianceGenome:MGI:2146285
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nop25
    Summary
    Predicted to enable identical protein binding activity; rRNA binding activity; and single-stranded DNA binding activity. Located in nucleolus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NOL12 (nucleolar protein 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 7.9), CNS E11.5 (RPKM 7.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nol12 in Genome Data Viewer
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78819151..78826111)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78934933..78941910)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E480 Neighboring gene pyridoxal (pyridoxine, vitamin B6) phosphatase Neighboring gene predicted gene, 30368 Neighboring gene STARR-positive B cell enhancer ABC_E10867 Neighboring gene lectin, galactose binding, soluble 1 Neighboring gene TRIO and F-actin binding protein Neighboring gene STARR-positive B cell enhancer ABC_E8975 Neighboring gene predicted gene 10865 Neighboring gene microRNA 6956 Neighboring gene predicted gene, 17753

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of Nop25, a novel nucleolar RNA binding protein, highly conserved in vertebrate species. Suzuki S, et al. Exp Cell Res, 2006 Apr 15. PMID 16430885
    2. Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. Rybkin II, et al. J Cell Biol, 2007 Nov 5. PMID 17984325, Free PMC Article
    3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleolar protein 12
    Names
    25 kDa nucleolar protein
    nucleolar protein of 25 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416121.1 → NP_001403050.1  nucleolar protein 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589670, AL831713

    2. NM_001416122.1 → NP_001403051.1  nucleolar protein 12 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL589670, AL831713

    3. NM_001416123.1 → NP_001403052.1  nucleolar protein 12 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL589670, AL831713

    4. NM_001416124.1 → NP_001403053.1  nucleolar protein 12 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL589670, AL831713

    5. NM_001416125.1 → NP_001403054.1  nucleolar protein 12 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL589670, AL831713

    6. NM_001416126.1 → NP_001403055.1  nucleolar protein 12 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL589670, AL831713

    7. NM_001416127.1 → NP_001403056.1  nucleolar protein 12 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL589670, AL831713

    8. NM_001416128.1 → NP_001403057.1  nucleolar protein 12 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL589670, AL831713
      UniProtKB/TrEMBL
      F8WGP0
      Related
      ENSMUSP00000042908.4, ENSMUST00000041164.4

    9. NM_001416129.1 → NP_001403058.1  nucleolar protein 12 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL589670, AL831713

    10. NM_133800.4 → NP_598561.2  nucleolar protein 12 isoform 1

      See identical proteins and their annotated locations for NP_598561.2

      Status: VALIDATED

      Source sequence(s)
      AL589670, AL831713
      Consensus CDS
      CCDS27629.1
      UniProtKB/Swiss-Prot
      Q8BG17, Q91VI1
      Related
      ENSMUSP00000116103.2, ENSMUST00000138880.9
      Conserved Domains (1) summary
      pfam09805
      Location:21 → 68
      Nop25; Nucleolar protein 12 (25kDa)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78819151..78826111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521605.5 → XP_006521668.1  nucleolar protein 12 isoform X1

      Conserved Domains (1) summary
      pfam09805
      Location:49 → 88
      Nop25; Nucleolar protein 12 (25kDa)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG17.1 GenPept UniProtKB/Swiss-Prot:Q8BG17

    Gene LinkOut

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