Hsf2 heat shock factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hsf2provided by MGI
Official Full Name: heat shock factor 2provided by MGI
Primary source: MGI:MGI:96239
See related: Ensembl:ENSMUSG00000019878 AllianceGenome:MGI:96239
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and identical protein binding activity. Acts upstream of or within spermatogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; future midbrain; genitourinary system; heart; and limb bud. Orthologous to human HSF2 (heat shock transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 5.1), CNS E14 (RPKM 4.1) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 29.19 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (57359862..57389239)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (57483766..57513143)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the findings of our studys suggest that HSF2 contributes to its own expression by forming a negative autoregulatory loop.
Title: HSF2 autoregulates its own transcription.
Set1/MLL complex is indispensable for the transcriptional ability of HSF2.
Title: Set1/MLL complex is indispensable for the transcriptional ability of heat shock transcription factor 2.
Authors have concluded that at the physiological temperature HSF1 and HSF2 cooperate in spermatogenic cells. However, temperature elevation causes remodeling of chromatin binding and interactions between HSFs are disrupted.
Title: Crosstalk between HSF1 and HSF2 during the heat shock response in mouse testes.
Thus, HSF2, as a sensor for alcohol stress in the fetal brain, acts as a mediator of the neuronal migration defects associated with fetal alcohol syndrome.
Title: Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome.
Results suggest that relative amounts of each heat shock factors HSF1 and HSF2 isoforms quantitatively determine the cellular level of the proteotoxic stress response.
Title: Unraveling complex interplay between heat shock factor 1 and 2 splicing isoforms.
The roles of trans (HSF 1 and 2) and cis (HSE) regulatory elements in the control of Hsp70.1 (Hspa1b) through several developmental steps from oocytes to blastocysts, was investigated.
Title: HSFs and regulation of Hsp70.1 (Hspa1b) in oocytes and preimplantation embryos: new insights brought by transgenic and knockout mouse models.
results reveal that miR-18 regulates HSF2 activity in spermatogenesis and link miR-18 to HSF2-mediated physiological processes such as male germ cell maturation.
Title: miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis.
a new role for HSF2 in the regulation of protein degradation and suggests that pan-HSF inhibitors could be valuable tools to reduce chemoresistance to proteasome inhibition observed in cancer therapy.
Title: Roles of heat shock factor 1 and 2 in response to proteasome inhibition: consequence on p53 stability.
A model in which the binding of HSF1, HSF2, and SP1 to the promoter of Hspa1b would allow the rapid formation of a transcription-competent state during the minor zygotic genome activation, thereby allowing Hspa1b expression.
Title: Interaction of HSF1 and HSF2 with the Hspa1b promoter in mouse epididymal spermatozoa.
HSF2 is required for correct chromatin organization in the sperm.
Title: Promoter ChIP-chip analysis in mouse testis reveals Y chromosome occupancy by HSF2.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hsf2 (e-PCR), detects polymorphism
- UniSTS:546825

NoName (e-PCR)
- UniSTS:236353

X61754 (e-PCR)
- UniSTS:163476

AI661205 (e-PCR)
- UniSTS:185829

Hsf2 (e-PCR), detects polymorphism
- UniSTS:546554

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heat shock factor protein 2

Names: HSF 2; HSTF 2; heat shock transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008297.3 → NP_032323.3 heat shock factor protein 2

See identical proteins and their annotated locations for NP_032323.3

Status: VALIDATED

Source sequence(s)

AK052270, AK053976, BB823041

Consensus CDS

CCDS23852.1

UniProtKB/TrEMBL

Q8BWK6

Related

ENSMUSP00000078761.5, ENSMUST00000079833.6

Conserved Domains (2) summary

smart00415
Location:6 → 110

HSF; heat shock factor

pfam06546
Location:230 → 493

Vert_HS_TF; Vertebrate heat shock transcription factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

57359862..57389239

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512564.4 → XP_006512627.1 heat shock factor protein 2 isoform X1

UniProtKB/Swiss-Prot

P38533, Q64157, Q8VEJ0, Q9Z2L8

Conserved Domains (2) summary

smart00415
Location:6 → 110

HSF; heat shock factor

pfam06546
Location:230 → 511

Vert_HS_TF; Vertebrate heat shock transcription factor
XM_006512565.5 → XP_006512628.1 heat shock factor protein 2 isoform X2

UniProtKB/Swiss-Prot

P38533, Q64157, Q8VEJ0, Q9Z2L8

UniProtKB/TrEMBL

A0A1W2P8F8

Related

ENSMUSP00000152013.2, ENSMUST00000220042.2

Conserved Domains (2) summary

smart00415
Location:1 → 53

HSF; heat shock factor

pfam06546
Location:173 → 454

Vert_HS_TF; Vertebrate heat shock transcription factor
XM_036155647.1 → XP_036011540.1 heat shock factor protein 2 isoform X3

UniProtKB/TrEMBL

Q8BWK6

Conserved Domains (2) summary

smart00415
Location:1 → 53

HSF; heat shock factor

pfam06546
Location:173 → 436

Vert_HS_TF; Vertebrate heat shock transcription factor