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    Sri sorcin [ Mus musculus (house mouse) ]

    Gene ID: 109552, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sriprovided by MGI
    Official Full Name
    sorcinprovided by MGI
    Primary source
    MGI:MGI:98419
    See related
    Ensembl:ENSMUSG00000003161 AllianceGenome:MGI:98419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sor; 2210417O06Rik; 2900070H08Rik
    Summary
    Enables DNA-binding transcription factor binding activity. Involved in cytoplasmic sequestering of transcription factor; negative regulation of cardiac muscle contraction; and positive regulation of transport. Acts upstream of or within calcium ion transport. Located in Z disc; plasma membrane; and vesicle. Orthologous to human SRI (sorcin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 54.9), large intestine adult (RPKM 37.3) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Sri in Genome Data Viewer
    Location:
    5 A1; 5 3.38 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8096078..8119314)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8046078..8069314)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12377 Neighboring gene STEAP family member 4 Neighboring gene STARR-seq mESC enhancer starr_12379 Neighboring gene predicted gene, 52802 Neighboring gene predicted gene 15731 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 22 Neighboring gene STARR-seq mESC enhancer starr_12380 Neighboring gene STARR-seq mESC enhancer starr_12381 Neighboring gene predicted gene, 21759 Neighboring gene predicted gene, 23993

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in cytoplasmic sequestering of transcription factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription regulatory region DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle cell contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cardiac muscle cell contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell communication by electrical coupling involved in cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell communication by electrical coupling involved in cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of high voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of relaxation of muscle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of relaxation of muscle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromaffin granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with chromaffin granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine neck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080974.2NP_001074443.1  sorcin isoform 1

      See identical proteins and their annotated locations for NP_001074443.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK134747, AK168572, BQ033487
      Consensus CDS
      CCDS39009.1
      UniProtKB/Swiss-Prot
      Q3UKC5, Q6P069, Q9CR38, Q9D7V8
      Related
      ENSMUSP00000118221.2, ENSMUST00000148633.4
      Conserved Domains (1) summary
      cd16187
      Location:34198
      EFh_PEF_sorcin; Penta-EF hand, calcium binding motifs, found in sorcin
    2. NM_025618.3NP_079894.2  sorcin isoform 2

      See identical proteins and their annotated locations for NP_079894.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK008404, AK008783, AK168572, BQ033487
      Consensus CDS
      CCDS19079.1
      UniProtKB/Swiss-Prot
      Q6P069
      Related
      ENSMUSP00000086165.5, ENSMUST00000088786.11
      Conserved Domains (2) summary
      cd00051
      Location:60115
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:97146
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      8096078..8119314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503527.1XP_006503590.1  sorcin isoform X1

      Conserved Domains (2) summary
      cd15897
      Location:1949
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:1113
      EFh_PEF; The penta-EF hand (PEF) family
    2. XM_017320600.3XP_017176089.1  sorcin isoform X1

      Conserved Domains (2) summary
      cd15897
      Location:1949
      EFh_PEF; EF-hand motif [structural motif]
      cl25352
      Location:1113
      EFh_PEF; The penta-EF hand (PEF) family