Trib3 tribbles pseudokinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trib3provided by MGI
Official Full Name: tribbles pseudokinase 3provided by MGI
Primary source: MGI:MGI:1345675
See related: Ensembl:ENSMUSG00000032715 AllianceGenome:MGI:1345675
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nipk; SINK; Trb3; Ifld2; SKIP3; TRB-3
Summary: Enables enzyme binding activity; transcription corepressor activity; and ubiquitin-protein transferase regulator activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of fat cell differentiation; and regulation of protein modification process. Located in nucleus. Is expressed in several structures, including bone; central nervous system; genitourinary system; heart; and retina. Orthologous to human TRIB3 (tribbles pseudokinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in duodenum adult (RPKM 4.6), small intestine adult (RPKM 3.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 74.83 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (152179345..152185980, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (152337425..152344060, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tribbles pseudokinase 3 promoted renal fibrosis by regulating the expression of DNA damage-inducible transcript 3 in diabetic nephropathy.
Title: Tribbles pseudokinase 3 promoted renal fibrosis by regulating the expression of DNA damage-inducible transcript 3 in diabetic nephropathy.
Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3.
Title: Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3.
TRIB3-TRIM8 complex drives NAFLD progression by regulating HNF4alpha stability.
Title: TRIB3-TRIM8 complex drives NAFLD progression by regulating HNF4α stability.
The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo.
Title: The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo.
Tribbles pseudokinase 3 promotes enterovirus A71 infection via dual mechanisms.
Title: Tribbles pseudokinase 3 promotes enterovirus A71 infection via dual mechanisms.
Stress-induced pseudokinase TRB3 augments IL1beta signaling by interacting with Flightless homolog 1.
Title: Stress-induced pseudokinase TRB3 augments IL1β signaling by interacting with Flightless homolog 1.
The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.
Title: The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.
Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration.
Title: Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration.
Tribbles Homolog 3 Mediates the Development and Progression of Diabetic Retinopathy.
Title: Tribbles Homolog 3 Mediates the Development and Progression of Diabetic Retinopathy.
Obesity-induced TRB3 negatively regulates Brown adipose tissue function in mice.
Title: Obesity-induced TRB3 negatively regulates Brown adipose tissue function in mice.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trib3 (e-PCR), detects polymorphism
- UniSTS:525618

C76863 (e-PCR)
- UniSTS:207428

NoName (e-PCR)
- UniSTS:235161

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables mitogen-activated protein kinase kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in positive regulation of ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tribbles homolog 3

Names: induced in fatty liver dystrophy 2; neuronal cell death-inducible putative kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175093.2 → NP_780302.2 tribbles homolog 3

See identical proteins and their annotated locations for NP_780302.2

Status: VALIDATED

Source sequence(s)

AK132257, BY010029

Consensus CDS

CCDS16881.1

UniProtKB/Swiss-Prot

Q3UMQ0, Q8K4K2, Q921E7

Related

ENSMUSP00000041747.7, ENSMUST00000040312.7

Conserved Domains (2) summary

smart00220
Location:71 → 315

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:74 → 315

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

152179345..152185980 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_144554.1: Suppressed sequence

Description

NM_144554.1: This RefSeq was permanently suppressed because there is insufficient support for the transcript and the protein.