Npat nuclear protein in the AT region [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npatprovided by MGI
Official Full Name: nuclear protein in the AT regionprovided by MGI
Primary source: MGI:MGI:107605
See related: Ensembl:ENSMUSG00000033054 AllianceGenome:MGI:107605
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6820401K01
Summary: Predicted to enable transcription coactivator activity and transcription corepressor activity. Acts upstream of or within in utero embryonic development. Predicted to be located in Cajal body; Gemini of coiled bodies; and cytoplasm. Predicted to be active in nucleus. Is expressed in inner cell mass. Orthologous to human NPAT (nuclear protein, coactivator of histone transcription). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 4.3), placenta adult (RPKM 4.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 29.12 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (53448347..53486867)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (53536889..53575627)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NPAT Supports CD8(+) Immature Single-Positive Thymocyte Proliferation and Thymic Development.
Title: NPAT Supports CD8(+) Immature Single-Positive Thymocyte Proliferation and Thymic Development.
Our data indicates that the function of Npat-dependent Sertoli cells is essential at multiple steps in testis development, and this study also identifies Sertoli cells as a major regulator of germ cell development, which are required to maintain a local growth niche to repress premature mitosis and meiosis of gonocytes.
Title: Npat-dependent programmed Sertoli cell proliferation is indispensable for testis cord development and germ cell mitotic arrest.
Data indicate that the CDK2/cyclin E/p220(NPAT)/HINFP/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis.
Title: The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles.
NPAT links E2F to the activation of S-phase-specific histone gene transcription.
Title: NPAT expression is regulated by E2F and is essential for cell cycle progression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI427561 (e-PCR)
- UniSTS:179899

BB112559 (e-PCR)
- UniSTS:185789

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell cycle G1/S phase transition	IEA Inferred from Electronic Annotation more info
involved_in cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in Cajal body	ISS Inferred from Sequence or Structural Similarity more info
located_in Gemini of coiled bodies	ISO Inferred from Sequence Orthology more info
located_in Gemini of coiled bodies	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein NPAT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081152.2 → NP_001074621.1 protein NPAT isoform 1

See identical proteins and their annotated locations for NP_001074621.1

Status: VALIDATED

Source sequence(s)

AC156640

Consensus CDS

CCDS40637.1

UniProtKB/Swiss-Prot

Q8BMA5, Q8BWA9, Q8BY06

Related

ENSMUSP00000048709.8, ENSMUST00000035850.8

Conserved Domains (1) summary

pfam15712
Location:755 → 1420

NPAT_C; NPAT C terminus
NM_001409956.1 → NP_001396885.1 protein NPAT isoform 2

Status: VALIDATED

Source sequence(s)

AC156640
NM_001434408.1 → NP_001421337.1 protein NPAT isoform 3

Status: VALIDATED

Source sequence(s)

AC156640

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

53448347..53486867

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242531.3 → XP_011240833.1 protein NPAT isoform X2

Conserved Domains (1) summary

pfam15712
Location:447 → 1113

NPAT_C; NPAT C-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_178905.2: Suppressed sequence

Description

NM_178905.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.