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    Itk IL2 inducible T cell kinase [ Mus musculus (house mouse) ]

    Gene ID: 16428, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itkprovided by MGI
    Official Full Name
    IL2 inducible T cell kinaseprovided by MGI
    Primary source
    MGI:MGI:96621
    See related
    Ensembl:ENSMUSG00000020395 AllianceGenome:MGI:96621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emt; Tsk; Tcsk
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including T cell receptor signaling pathway; gamma-delta T cell activation; and protein phosphorylation. Acts upstream of or within NK T cell differentiation. Located in cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 35.8), spleen adult (RPKM 4.7) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Itk in Genome Data Viewer
    Location:
    11 B1.1; 11 27.75 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (46215975..46280342, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46325148..46389515, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cytoplasmic FMR1 interacting protein 2 Neighboring gene fibronectin type III domain containing 9 Neighboring gene high mobility group box 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46124833-46125038 Neighboring gene STARR-positive B cell enhancer ABC_E8394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46140340-46140549 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46157730-46157921 Neighboring gene predicted gene 12167 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46202936-46203219 Neighboring gene STARR-positive B cell enhancer ABC_E3943 Neighboring gene STARR-seq mESC enhancer starr_29325 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46234578-46234761 Neighboring gene golgi associated RAB2 interactor 3 Neighboring gene STARR-seq mESC enhancer starr_29326 Neighboring gene STARR-positive B cell enhancer ABC_E1415 Neighboring gene mediator complex subunit 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (5) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in NK T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within NK T cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within NK T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adaptive immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gamma-delta T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within interleukin-4 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within interleukin-4 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within type II interferon production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase ITK/TSK
    Names
    T-cell-specific kinase
    interleukin-2-inducible T cell kinase
    kinase TLK
    NP_001268894.1
    NP_001268895.1
    NP_001268896.1
    NP_001268897.1
    NP_034713.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281965.1NP_001268894.1  tyrosine-protein kinase ITK/TSK isoform 1

      See identical proteins and their annotated locations for NP_001268894.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK153613, AL662806, BB843988, BY589043, D14042
      Consensus CDS
      CCDS70169.1
      UniProtKB/Swiss-Prot
      Q03526
      UniProtKB/TrEMBL
      Q3U5G1
      Related
      ENSMUSP00000104860.3, ENSMUST00000109237.9
      Conserved Domains (4) summary
      cd05112
      Location:363618
      PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
      cd10396
      Location:238345
      SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
      cd11908
      Location:180235
      SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
      cd01238
      Location:7154
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    2. NM_001281966.1NP_001268895.1  tyrosine-protein kinase ITK/TSK isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AK153613, BB843988, BY589043, D14042
      UniProtKB/TrEMBL
      Q3U5G1
      Conserved Domains (4) summary
      cd05112
      Location:360615
      PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
      cd10396
      Location:235342
      SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
      cd11908
      Location:177232
      SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
      cd01238
      Location:7148
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    3. NM_001281967.1NP_001268896.1  tyrosine-protein kinase ITK/TSK isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BB843988, BC028478
      Consensus CDS
      CCDS70168.1
      UniProtKB/TrEMBL
      Q5STT7
      Related
      ENSMUSP00000098864.4, ENSMUST00000101306.4
      Conserved Domains (4) summary
      cd11908
      Location:174229
      SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
      cd01238
      Location:7148
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      pfam00169
      Location:5111
      PH; PH domain
      cl15255
      Location:232259
      SH2; Src homology 2 (SH2) domain
    4. NM_001281968.1NP_001268897.1  tyrosine-protein kinase ITK/TSK isoform 5

      See identical proteins and their annotated locations for NP_001268897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (5) is shorter, compared to isoform 1.
      Source sequence(s)
      AK153613, BB843988, BY589043, D14042
      UniProtKB/TrEMBL
      A1A560, Q3U5G1
      Conserved Domains (4) summary
      cd05112
      Location:356611
      PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
      cd10396
      Location:231338
      SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
      cd11908
      Location:173228
      SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
      cd01238
      Location:7147
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    5. NM_010583.3NP_034713.2  tyrosine-protein kinase ITK/TSK isoform 2

      See identical proteins and their annotated locations for NP_034713.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK153613, BB843988, BY589043, D14042
      Consensus CDS
      CCDS24575.2
      UniProtKB/TrEMBL
      Q3U5G1, Q5STT8
      Related
      ENSMUSP00000020664.7, ENSMUST00000020664.13
      Conserved Domains (4) summary
      cd05112
      Location:357612
      PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
      cd10396
      Location:232339
      SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
      cd11908
      Location:174229
      SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
      cd01238
      Location:7148
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      46215975..46280342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)