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    Ube2q2l ubiquitin conjugating enzyme E2 Q2 like [ Mus musculus (house mouse) ]

    Gene ID: 100502936, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ube2q2lprovided by MGI
    Official Full Name
    ubiquitin conjugating enzyme E2 Q2 likeprovided by MGI
    Primary source
    MGI:MGI:2141773
    See related
    Ensembl:ENSMUSG00000045291 AllianceGenome:MGI:2141773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E330021D16Rik
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination. Predicted to be active in nucleus. Orthologous to human UBE2Q2 (ubiquitin conjugating enzyme E2 Q2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in ovary adult (RPKM 3.0), placenta adult (RPKM 0.8) and 2 other tissues See more
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    Genomic context

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    See Ube2q2l in Genome Data Viewer
    Location:
    6 G1; 6 66.59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136377310..136396870, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136400312..136419873, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 707 pseudogene Neighboring gene tubulin, beta 3 class III, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_17592 Neighboring gene predicted gene, 36844 Neighboring gene predicted gene, 53345

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 Q2-like
    Names
    ubiquitin-conjugating enzyme E2Q (putative) 2 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201390.1 → NP_001188319.1  ubiquitin-conjugating enzyme E2 Q2-like

      See identical proteins and their annotated locations for NP_001188319.1

      Status: VALIDATED

      Source sequence(s)
      AK054382, BM228571
      Consensus CDS
      CCDS51940.1
      UniProtKB/TrEMBL
      Q3TS71, Q8BW45
      Related
      ENSMUSP00000145343.2, ENSMUST00000204830.2
      Conserved Domains (2) summary
      cl00154
      Location:203 → 328
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl02687
      Location:8 → 88
      RWD; RWD domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      136377310..136396870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505223.5 → XP_006505286.1  ubiquitin-conjugating enzyme E2 Q2-like isoform X1

      See identical proteins and their annotated locations for XP_006505286.1

      UniProtKB/TrEMBL
      Q3TS71, Q8BW45
      Conserved Domains (2) summary
      cl00154
      Location:203 → 328
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl02687
      Location:8 → 88
      RWD; RWD domain

    2. XM_011241098.3 → XP_011239400.1  ubiquitin-conjugating enzyme E2 Q2-like isoform X1

      See identical proteins and their annotated locations for XP_011239400.1

      UniProtKB/TrEMBL
      Q3TS71, Q8BW45
      Conserved Domains (2) summary
      cl00154
      Location:203 → 328
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl02687
      Location:8 → 88
      RWD; RWD domain

    3. XM_011241097.3 → XP_011239399.1  ubiquitin-conjugating enzyme E2 Q2-like isoform X1

      See identical proteins and their annotated locations for XP_011239399.1

      UniProtKB/TrEMBL
      Q3TS71, Q8BW45
      Conserved Domains (2) summary
      cl00154
      Location:203 → 328
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl02687
      Location:8 → 88
      RWD; RWD domain

    4. XM_011241096.1 → XP_011239398.1  ubiquitin-conjugating enzyme E2 Q2-like isoform X1

      See identical proteins and their annotated locations for XP_011239398.1

      UniProtKB/TrEMBL
      Q3TS71, Q8BW45
      Conserved Domains (2) summary
      cl00154
      Location:203 → 328
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl02687
      Location:8 → 88
      RWD; RWD domain
    Nucleotide Protein Strain
    Heading Accession and Version

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