Trpm2 transient receptor potential cation channel, subfamily M, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpm2provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily M, member 2provided by MGI
Primary source: MGI:MGI:1351901
See related: Ensembl:ENSMUSG00000009292 AllianceGenome:MGI:1351901
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trp7; TRPC7; Trrp7; LTRPC2; 9830168K16Rik
Summary: Enables ligand-gated calcium channel activity and manganese ion transmembrane transporter activity. Involved in several processes, including calcium ion transmembrane import into cytosol; cellular response to temperature stimulus; and dendritic cell chemotaxis. Acts upstream of or within manganese ion transport and response to hydroperoxide. Located in cytoplasmic vesicle membrane; lysosomal membrane; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 10.5), cerebellum adult (RPKM 4.0) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (77743556..77805746, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (77907722..77969909, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia.
Title: TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia.
Neurodegeneration and glial morphological changes are both prevented by TRPM2 inhibition during the progression of a Parkinson's disease mouse model.
Title: Neurodegeneration and glial morphological changes are both prevented by TRPM2 inhibition during the progression of a Parkinson's disease mouse model.
Activation of endothelial TRPM2 exacerbates blood-brain barrier degradation in ischemic stroke.
Title: Activation of endothelial TRPM2 exacerbates blood-brain barrier degradation in ischemic stroke.
Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation.
Title: Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation.
The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice.
Title: The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice.
Severe inflammation in C57/BL6 mice leads to prolonged cognitive impairment by initiating the IL-1beta/TRPM2 pathway.
Title: Severe inflammation in C57/BL6 mice leads to prolonged cognitive impairment by initiating the IL-1β/TRPM2 pathway.
TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis.
Title: TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis.
TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy.
Title: TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy.
Clusterin regulates TRPM2 to protect against myocardial injury induced by acute myocardial infarction injury.
Title: Clusterin regulates TRPM2 to protect against myocardial injury induced by acute myocardial infarction injury.
Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis.
Title: Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis.

Submit: New GeneRIF Correction See all GeneRIFs (116)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpm2 (e-PCR), detects polymorphism
- UniSTS:531246

NoName (e-PCR)
- UniSTS:491056

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Trpm2 (e-PCR), detects polymorphism
- UniSTS:259667

Trpm2 (e-PCR), detects polymorphism
- UniSTS:259162

Trpm2 (e-PCR), detects polymorphism
- UniSTS:530850

RH126617 (e-PCR)
- UniSTS:208563

D10Jhu45 (e-PCR), detects polymorphism
- UniSTS:158701

D10Jhu46 (e-PCR), detects polymorphism
- UniSTS:158702

D10Jhu47 (e-PCR), detects polymorphism
- UniSTS:158703

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables ADP-ribose diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
NOT enables hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables intracellularly gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables ligand-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables manganese ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables mono-ADP-D-ribose binding	ISO Inferred from Sequence Orthology more info
enables mono-ADP-D-ribose binding	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane import into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in manganese ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within manganese ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hydroperoxide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to purine-containing compound	IEA Inferred from Electronic Annotation more info
involved_in response to purine-containing compound	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily M member 2

Names: LTrpC-2; long transient receptor potential channel 2; transient receptor potential channel 7; transient receptor protein 7

NP_001398829.1

EC 3.6.1.13

NP_612174.2

EC 3.6.1.13

XP_006513793.1

EC 3.6.1.13

XP_006513794.1

EC 3.6.1.13

XP_006513795.1

EC 3.6.1.13

XP_006513796.1

EC 3.6.1.13

XP_011241772.1

EC 3.6.1.13

XP_017169449.1

EC 3.6.1.13

XP_017169451.1

EC 3.6.1.13

XP_036011694.1

EC 3.6.1.13

XP_036011695.1

EC 3.6.1.13

XP_036011696.1

EC 3.6.1.13

XP_036011697.1

EC 3.6.1.13

XP_036011698.1

EC 3.6.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411900.1 → NP_001398829.1 transient receptor potential cation channel subfamily M member 2

Status: VALIDATED

Source sequence(s)

AC153507, AC158612

UniProtKB/Swiss-Prot

Q5KTC0, Q91YD4

Related

ENSMUST00000105400.9
NM_138301.2 → NP_612174.2 transient receptor potential cation channel subfamily M member 2

See identical proteins and their annotated locations for NP_612174.2

Status: VALIDATED

Source sequence(s)

AC153507, AC158612, AK036731, AK134735, AK136905, CJ108999

Consensus CDS

CCDS48611.1

UniProtKB/Swiss-Prot

Q5KTC0, Q91YD4

Related

ENSMUSP00000101040.3, ENSMUST00000105401.9

Conserved Domains (4) summary

TIGR00870
Location:716 → 1071

trp; transient-receptor-potential calcium channel protein

pfam00520
Location:800 → 976

Ion_trans; Ion transport protein

cl00447
Location:1322 → 1502

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

77743556..77805746 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513731.5 → XP_006513794.1 transient receptor potential cation channel subfamily M member 2 isoform X3

UniProtKB/TrEMBL

Q3UYE9

Conserved Domains (3) summary

TIGR00870
Location:189 → 544

trp; transient-receptor-potential calcium channel protein

pfam00520
Location:273 → 421

Ion_trans; Ion transport protein

cl00447
Location:795 → 975

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_006513732.2 → XP_006513795.1 transient receptor potential cation channel subfamily M member 2 isoform X4

UniProtKB/TrEMBL

Q3UYE9

Conserved Domains (3) summary

TIGR00870
Location:185 → 540

trp; transient-receptor-potential calcium channel protein

pfam00520
Location:269 → 417

Ion_trans; Ion transport protein

cl00447
Location:791 → 971

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_036155801.1 → XP_036011694.1 transient receptor potential cation channel subfamily M member 2 isoform X7

Conserved Domains (2) summary

pfam00520
Location:7 → 123

Ion_trans; Ion transport protein

cl00447
Location:469 → 649

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_017313962.2 → XP_017169451.1 transient receptor potential cation channel subfamily M member 2 isoform X10

Conserved Domains (1) summary

cl00447
Location:47 → 227

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_036155803.1 → XP_036011696.1 transient receptor potential cation channel subfamily M member 2 isoform X9

Conserved Domains (1) summary

cl00447
Location:73 → 253

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_036155804.1 → XP_036011697.1 transient receptor potential cation channel subfamily M member 2 isoform X10

Conserved Domains (1) summary

cl00447
Location:47 → 227

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_017313960.2 → XP_017169449.1 transient receptor potential cation channel subfamily M member 2 isoform X7

Conserved Domains (2) summary

pfam00520
Location:7 → 123

Ion_trans; Ion transport protein

cl00447
Location:469 → 649

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_036155805.1 → XP_036011698.1 transient receptor potential cation channel subfamily M member 2 isoform X10

Conserved Domains (1) summary

cl00447
Location:47 → 227

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_036155802.1 → XP_036011695.1 transient receptor potential cation channel subfamily M member 2 isoform X8

Conserved Domains (1) summary

cl00447
Location:168 → 348

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_006513730.3 → XP_006513793.1 transient receptor potential cation channel subfamily M member 2 isoform X2

Conserved Domains (2) summary

pfam00520
Location:800 → 948

Ion_trans; Ion transport protein

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM
XM_011243470.4 → XP_011241772.1 transient receptor potential cation channel subfamily M member 2 isoform X5

Conserved Domains (1) summary

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM
XM_006513733.5 → XP_006513796.1 transient receptor potential cation channel subfamily M member 2 isoform X6

Conserved Domains (1) summary

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM