Prmt3 protein arginine methyltransferase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prmt3provided by RGD
Official Full Name: protein arginine methyltransferase 3provided by RGD
Primary source: RGD:620413
See related: EnsemblRapid:ENSRNOG00000014829 AllianceGenome:RGD:620413
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hrmt1l3
Summary: Enables modified amino acid binding activity and protein-arginine omega-N asymmetric methyltransferase activity. Involved in dendritic spine morphogenesis and peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Predicted to be located in cytosol. Predicted to be active in nucleus. Biomarker of asthma. Orthologous to human PRMT3 (protein arginine methyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 111.1), Spleen (RPKM 108.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (108628899..108718803)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (99492712..99581774)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (105113595..105200253)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suggest that interaction between PRMT3 and RhoGDI-alpha mediates mycophenolic acid-induced pancreatic beta-cell death.
Title: PRMT3: new binding molecule to RhoGDI-α during mycophenolic acid-induced β-cell death.
PRMT3 possibly plays a pivotal role in neuronal translation by contributing to activity-dependent changes in the dendritic spines.
Title: PRMT3 is essential for dendritic spine maturation in rat hippocampal neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141582 (e-PCR)
- UniSTS:223576

Prmt3 (e-PCR), detects polymorphism
- UniSTS:479206

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables histone methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables modified amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine omega-N monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of retinoic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of retinoic acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-arginine methylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IDA Inferred from Direct Assay more info	PubMed
involved_in protein methylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein arginine N-methyltransferase 3

Names: heterogeneous nuclear ribonucleoprotein methyltransferase-like 3; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3; protein arginine N-methyltransferase 3(hnRNP methyltransferase S. cerevisiae)-like 3

NP_446009.1

EC 2.1.1.319

XP_038949056.1

EC 2.1.1.319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053557.2 → NP_446009.1 protein arginine N-methyltransferase 3

See identical proteins and their annotated locations for NP_446009.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O70467

UniProtKB/TrEMBL

A0A8L2QAU2, A6JBG4

Related

ENSRNOP00000020853.5, ENSRNOT00000020853.7

Conserved Domains (2) summary

cd02440
Location:256 → 356

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam12756
Location:48 → 97

zf-C2H2_2; C2H2 type zinc-finger (2 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

108628899..108718803

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093128.2 → XP_038949056.1 protein arginine N-methyltransferase 3 isoform X1

UniProtKB/TrEMBL

A0A0G2JW52, A0A8L2QAU2

Related

ENSRNOP00000069745.2, ENSRNOT00000079655.3

Conserved Domains (2) summary

cd02440
Location:256 → 356

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam12756
Location:48 → 97

zf-C2H2_2; C2H2 type zinc-finger (2 copies)