Slc12a2 solute carrier family 12 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc12a2provided by RGD
Official Full Name: solute carrier family 12 member 2provided by RGD
Primary source: RGD:620809
See related: EnsemblRapid:ENSRNOG00000015971 AllianceGenome:RGD:620809
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bsc2; Nkcc1
Summary: Enables sodium:potassium:chloride symporter activity. Involved in several processes, including chloride transport; metal ion transport; and positive regulation of cell volume. Acts upstream of or within gamma-aminobutyric acid signaling pathway and regulation of spontaneous synaptic transmission. Predicted to be located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and neuronal cell body. Predicted to be active in apical plasma membrane. Used to study hypertension; middle cerebral artery infarction; and visual epilepsy. Biomarker of hypertension; sensorineural hearing loss; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 78. Orthologous to human SLC12A2 (solute carrier family 12 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 351.2), Muscle (RPKM 334.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (53546263..53614478)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (51348282..51416448)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (52917124..52985281)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development.
Title: DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development.
NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons.
Title: NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons.
Dietary Na[+] depletion up-regulates NKCC1 expression and enhances electrogenic Cl[-] secretion in rat proximal colon.
Title: Dietary Na(+) depletion up-regulates NKCC1 expression and enhances electrogenic Cl(-) secretion in rat proximal colon.
Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1.
Title: Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1.
NLRP3 inflammasome-mediated choroid plexus hypersecretion contributes to hydrocephalus after intraventricular hemorrhage via phosphorylated NKCC1 channels.
Title: NLRP3 inflammasome-mediated choroid plexus hypersecretion contributes to hydrocephalus after intraventricular hemorrhage via phosphorylated NKCC1 channels.
Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.
Title: Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.
Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics.
Title: Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics.
Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation.
Title: Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation.
NKCC-1 mediated Cl(-) uptake in immature CA3 pyramidal neurons is sufficient to compensate phasic GABAergic inputs.
Title: NKCC-1 mediated Cl(-) uptake in immature CA3 pyramidal neurons is sufficient to compensate phasic GABAergic inputs.
Acute Hyperglycemia Aggravates Lung Injury via Activation of the SGK1-NKCC1 Pathway.
Title: Acute Hyperglycemia Aggravates Lung Injury via Activation of the SGK1-NKCC1 Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (80)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF403957 (e-PCR)
- UniSTS:246536

RH139514 (e-PCR)
- UniSTS:221600

RH137302 (e-PCR)
- UniSTS:219390

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables ammonium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ammonium channel activity	ISO Inferred from Sequence Orthology more info
enables chloride:monoatomic cation symporter activity	ISO Inferred from Sequence Orthology more info
enables chloride:monoatomic cation symporter activity	TAS Traceable Author Statement more info	PubMed
enables metal ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables potassium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables sodium:potassium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:potassium:chloride symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium:potassium:chloride symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in ammonium transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ammonium transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to potassium ion	ISO Inferred from Sequence Orthology more info
involved_in chloride ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inorganic anion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of blood-brain barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary duct terminal end bud growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of vascular wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of aspartate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of matrix metallopeptidase secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of spontaneous synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of spontaneous synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transepithelial ammonium transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial chloride transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 12 member 2

Names: solute carrier family 12 (sodium/potassium/chloride transporter), member 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031798.2 → NP_113986.2 solute carrier family 12 member 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

E9PTX9, Q9QX10

Related

ENSRNOP00000021921.4, ENSRNOT00000021921.6

Conserved Domains (1) summary

TIGR00930
Location:207 → 1203

2a30; K-Cl cotransporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

53546263..53614478

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254752.5 → XP_006254814.1 solute carrier family 12 member 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZP25, Q9QX10

Related

ENSRNOP00000079755.1, ENSRNOT00000102056.2

Conserved Domains (4) summary

TIGR00930
Location:207 → 1187

2a30; K-Cl cotransporter

pfam03522
Location:792 → 1187

SLC12; Solute carrier family 12

pfam08403
Location:193 → 254

AA_permease_N; Amino acid permease N-terminal

pfam15772
Location:3 → 68

UPF0688; UPF0688 family