U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Arhgef4 Rho guanine nucleotide exchange factor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301334, updated on 27-Nov-2024

    Summary

    Official Symbol
    Arhgef4provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 4provided by RGD
    Primary source
    RGD:1586179
    See related
    EnsemblRapid:ENSRNOG00000014035 AllianceGenome:RGD:1586179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Predicted to be involved in filopodium assembly and lamellipodium assembly. Predicted to be active in cytosol. Orthologous to human ARHGEF4 (Rho guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 152.4), Thymus (RPKM 45.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arhgef4 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44357716..44500959)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (36861800..37005079)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (41160562..41305015)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene thymosin beta-10-like Neighboring gene ribosomal protein lateral stalk subunit P1, pseudogene 1 Neighboring gene uncharacterized LOC120094663 Neighboring gene small integral membrane protein 39 Neighboring gene family with sequence similarity 168, member B Neighboring gene uncharacterized LOC120094662 Neighboring gene pleckstrin homology domain containing B2 Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 4
    Names
    Rho guanine nucleotide exchange factor (GEF) 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427642.1NP_001414571.1  rho guanine nucleotide exchange factor 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D3ZKB4
      Related
      ENSRNOP00000018935.6, ENSRNOT00000018935.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      44357716..44500959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084525.2XP_038940453.1  rho guanine nucleotide exchange factor 4 isoform X2

      Conserved Domains (3) summary
      cd11973
      Location:11411213
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:12501429
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01224
      Location:14341573
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    2. XM_063266890.1XP_063122960.1  rho guanine nucleotide exchange factor 4 isoform X4

    3. XM_017596787.3XP_017452276.1  rho guanine nucleotide exchange factor 4 isoform X1

    4. XM_063266889.1XP_063122959.1  rho guanine nucleotide exchange factor 4 isoform X3

    5. XM_063266891.1XP_063122961.1  rho guanine nucleotide exchange factor 4 isoform X5

      Related
      ENSRNOP00000103915.1, ENSRNOT00000135503.1